Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”

Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”

Summary: Various stress conditions are signaled through phosphorylation of translation initiation factor eukaryotic initiation factor 2α (eIF2α) to inhibit global translation while selectively activating transcription factor ATF4 to aid cell survival and recovery. However, this integrated stress res...

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Bibliographic Details
Main Authors: Julia A. Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R. Yates, III, Taisuke Kanaji, Xiang-Lei Yang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006435

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