Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity
Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patien...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00236/full |
| _version_ | 1818259264528973824 |
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| author | Richard Ang Nephtali Marina Nephtali Marina |
| author_facet | Richard Ang Nephtali Marina Nephtali Marina |
| author_sort | Richard Ang |
| collection | DOAJ |
| description | Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial infarction that is believed to occur in association with low-frequency oscillations in sympathetic nerve activity. However, this hypothesis is based on associations of PRD with indices of sympathetic activity that are not directly linked to cardiac function, such as muscle vasoconstrictor activity and the variability of cardiovascular autospectra. In this review article, we critically evaluate existing scientific evidence obtained primarily in experimental animal models, with the aim of identifying the neuronal networks responsible for the generation of low-frequency sympathetic rhythms along the neurocardiac axis. We discuss the functional significance of rhythmic sympathetic activity on neurotransmission efficacy and explore its role in the pathogenesis of ventricular repolarization instability. Most importantly, we discuss important gaps in our knowledge that require further investigation in order to confirm the hypothesis that low frequency cardiac sympathetic oscillations play a causative role in the generation of PRD. |
| first_indexed | 2024-12-12T18:12:41Z |
| format | Article |
| id | doaj.art-a0ead2d4f61641dabf25f2c79ab19937 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T18:12:41Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a0ead2d4f61641dabf25f2c79ab199372022-12-22T00:16:21ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-03-011110.3389/fphys.2020.00236521675Low-Frequency Oscillations in Cardiac Sympathetic Neuronal ActivityRichard Ang0Nephtali Marina1Nephtali Marina2Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, United KingdomCentre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, United KingdomDivision of Medicine, University College London, London, United KingdomSudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial infarction that is believed to occur in association with low-frequency oscillations in sympathetic nerve activity. However, this hypothesis is based on associations of PRD with indices of sympathetic activity that are not directly linked to cardiac function, such as muscle vasoconstrictor activity and the variability of cardiovascular autospectra. In this review article, we critically evaluate existing scientific evidence obtained primarily in experimental animal models, with the aim of identifying the neuronal networks responsible for the generation of low-frequency sympathetic rhythms along the neurocardiac axis. We discuss the functional significance of rhythmic sympathetic activity on neurotransmission efficacy and explore its role in the pathogenesis of ventricular repolarization instability. Most importantly, we discuss important gaps in our knowledge that require further investigation in order to confirm the hypothesis that low frequency cardiac sympathetic oscillations play a causative role in the generation of PRD.https://www.frontiersin.org/article/10.3389/fphys.2020.00236/fullsympatheticarrhythmiaoscillationscardiac repolarizationcardiac innervation |
| spellingShingle | Richard Ang Nephtali Marina Nephtali Marina Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity Frontiers in Physiology sympathetic arrhythmia oscillations cardiac repolarization cardiac innervation |
| title | Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity |
| title_full | Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity |
| title_fullStr | Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity |
| title_full_unstemmed | Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity |
| title_short | Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity |
| title_sort | low frequency oscillations in cardiac sympathetic neuronal activity |
| topic | sympathetic arrhythmia oscillations cardiac repolarization cardiac innervation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00236/full |
| work_keys_str_mv | AT richardang lowfrequencyoscillationsincardiacsympatheticneuronalactivity AT nephtalimarina lowfrequencyoscillationsincardiacsympatheticneuronalactivity AT nephtalimarina lowfrequencyoscillationsincardiacsympatheticneuronalactivity |