Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

Colorectal cancer is a major cause of cancer death and approximately 20% arises within serrated polyps, which are under-recognized and poorly understood. Human serrated colorectal polyps frequently exhibit both oncogenic BRAF mutation and widespread DNA methylation changes, which are important in si...

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Bibliographic Details
Main Authors: Catherine E. Bond, Cheng Liu, Futoshi Kawamata, Diane M. McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L. Woods, Tamsin R. M. Lannagan, Roshini Somashekar, Young Lee, Troy Dumenil, Gunter Hartel, Kevin J. Spring, Jennifer Borowsky, Lochlan Fennell, Mark Bettington, Jason Lee, Daniel L. Worthley, Barbara A. Leggett, Vicki L. J. Whitehall
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Epigenetics
Subjects:
braf
cancer biology
colorectal cancer
dna methylation
methylation
murine model
serrated neoplasia
Online Access:http://dx.doi.org/10.1080/15592294.2017.1411446

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