T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship
Co-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tuning of T-cell dependent antibody responses. While th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01941/full |
| _version_ | 1818293391635513344 |
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| author | Lina Petersone Natalie M. Edner Vitalijs Ovcinnikovs Frank Heuts Ellen M. Ross Elisavet Ntavli Chun J. Wang Lucy S. K. Walker |
| author_facet | Lina Petersone Natalie M. Edner Vitalijs Ovcinnikovs Frank Heuts Ellen M. Ross Elisavet Ntavli Chun J. Wang Lucy S. K. Walker |
| author_sort | Lina Petersone |
| collection | DOAJ |
| description | Co-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tuning of T-cell dependent antibody responses. While these processes have evolved to permit rapid immune defense against infection, it is becoming increasingly clear that such interactions can also underpin the development of autoimmunity. Here we discuss a selection of cellular and molecular pathways that mediate T cell/B cell collaboration and highlight how in vivo models and genome wide association studies link them with autoimmune disease. In particular, we emphasize how CTLA-4-mediated regulation of CD28 signaling controls the engagement of secondary costimulatory pathways such as ICOS and OX40, and profoundly influences the capacity of T cells to provide B cell help. While our molecular understanding of the co-operation between T cells and B cells derives from analysis of secondary lymphoid tissues, emerging evidence suggests that subtly different rules may govern the interaction of T and B cells at ectopic sites during autoimmune inflammation. Accordingly, the phenotype of the T cells providing help at these sites includes notable distinctions, despite sharing core features with T cells imparting help in secondary lymphoid tissues. Finally, we highlight the interdependence of T cell and B cell responses and suggest that a significant beneficial impact of B cell depletion in autoimmune settings may be its detrimental effect on T cells engaged in molecular conversation with B cells. |
| first_indexed | 2024-12-13T03:15:07Z |
| format | Article |
| id | doaj.art-a0edfa3c98b64d6e92fe1077110a0a54 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T03:15:07Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a0edfa3c98b64d6e92fe1077110a0a542022-12-22T00:01:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-08-01910.3389/fimmu.2018.01941405285T Cell/B Cell Collaboration and Autoimmunity: An Intimate RelationshipLina PetersoneNatalie M. EdnerVitalijs OvcinnikovsFrank HeutsEllen M. RossElisavet NtavliChun J. WangLucy S. K. WalkerCo-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tuning of T-cell dependent antibody responses. While these processes have evolved to permit rapid immune defense against infection, it is becoming increasingly clear that such interactions can also underpin the development of autoimmunity. Here we discuss a selection of cellular and molecular pathways that mediate T cell/B cell collaboration and highlight how in vivo models and genome wide association studies link them with autoimmune disease. In particular, we emphasize how CTLA-4-mediated regulation of CD28 signaling controls the engagement of secondary costimulatory pathways such as ICOS and OX40, and profoundly influences the capacity of T cells to provide B cell help. While our molecular understanding of the co-operation between T cells and B cells derives from analysis of secondary lymphoid tissues, emerging evidence suggests that subtly different rules may govern the interaction of T and B cells at ectopic sites during autoimmune inflammation. Accordingly, the phenotype of the T cells providing help at these sites includes notable distinctions, despite sharing core features with T cells imparting help in secondary lymphoid tissues. Finally, we highlight the interdependence of T cell and B cell responses and suggest that a significant beneficial impact of B cell depletion in autoimmune settings may be its detrimental effect on T cells engaged in molecular conversation with B cells.https://www.frontiersin.org/article/10.3389/fimmu.2018.01941/fullfollicular helper T cells (Tfh)B cellsgerminal centerautoimmunitycostimulationCD28 |
| spellingShingle | Lina Petersone Natalie M. Edner Vitalijs Ovcinnikovs Frank Heuts Ellen M. Ross Elisavet Ntavli Chun J. Wang Lucy S. K. Walker T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship Frontiers in Immunology follicular helper T cells (Tfh) B cells germinal center autoimmunity costimulation CD28 |
| title | T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship |
| title_full | T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship |
| title_fullStr | T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship |
| title_full_unstemmed | T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship |
| title_short | T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship |
| title_sort | t cell b cell collaboration and autoimmunity an intimate relationship |
| topic | follicular helper T cells (Tfh) B cells germinal center autoimmunity costimulation CD28 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01941/full |
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