Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report
Abstract Background Maintenance therapy using poly(adenosine diphosphate-ribose)polymerase inhibitors may have adverse events, including hematological toxicity, and may limit therapeutic potential in patients with cancer. Niraparib-induced anemia negatively impacts one’s quality of life. Its amelior...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03666-3 |
| _version_ | 1811187090393661440 |
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| author | Hiroshi Kobayashi Yuki Yamada |
| author_facet | Hiroshi Kobayashi Yuki Yamada |
| author_sort | Hiroshi Kobayashi |
| collection | DOAJ |
| description | Abstract Background Maintenance therapy using poly(adenosine diphosphate-ribose)polymerase inhibitors may have adverse events, including hematological toxicity, and may limit therapeutic potential in patients with cancer. Niraparib-induced anemia negatively impacts one’s quality of life. Its amelioration by ferrous iron (for example, sodium ferrous citrate), folic acid, or vitamin B12 has not been supported. Oral ferric citrate hydrate increases circulating levels of iron and hepatic iron accumulation, improving renal anemia in patients with kidney failure receiving hemodialysis. The uptake of ferric iron is considered to be much higher than that of ferrous iron. Case presentation The admitted patient was a 57-year-old Japanese woman with stage IIIB ovarian cancer who underwent primary debulking surgery and standard carboplatin–paclitaxel chemotherapy combined with bevacizumab, followed by niraparib (200 mg/day) maintenance therapy. The patient started oral SFC (100 mg/day) to treat niraparib-related anemia. However, she required two units of packed red blood cell transfusions three times within 3 months after starting niraparib treatment. The patient was diagnosed with niraparib-related anemia. The blood test results after 1 month from the start of niraparib treatment were as follows: red blood cells, 211 × 104/μL; hemoglobin, 7.0 g/dL; hematocrit, 20.8%; reticulocyte, 0.2%; platelet count, 18.0 × 104/μL. She was switched to oral ferric citrate hydrate with a dose of 500 mg per day and resumed niraparib treatment. She did not experience grade 3 niraparib-related hematological toxicity and achieved blood transfusion independence. Conclusions Ferric citrate hydrate may be a safe, effective, and well-tolerated oral drug for treating patients with niraparib-related anemia. |
| first_indexed | 2024-04-11T13:56:09Z |
| format | Article |
| id | doaj.art-a0f028592dbf4f6bbf78ba1560246f34 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-11T13:56:09Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-a0f028592dbf4f6bbf78ba1560246f342022-12-22T04:20:20ZengBMCJournal of Medical Case Reports1752-19472022-11-011611710.1186/s13256-022-03666-3Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case reportHiroshi Kobayashi0Yuki Yamada1Department of Obstetrics and Gynecology, Ms.Clinic MayOneDepartment of Obstetrics and Gynecology, Nara Medical UniversityAbstract Background Maintenance therapy using poly(adenosine diphosphate-ribose)polymerase inhibitors may have adverse events, including hematological toxicity, and may limit therapeutic potential in patients with cancer. Niraparib-induced anemia negatively impacts one’s quality of life. Its amelioration by ferrous iron (for example, sodium ferrous citrate), folic acid, or vitamin B12 has not been supported. Oral ferric citrate hydrate increases circulating levels of iron and hepatic iron accumulation, improving renal anemia in patients with kidney failure receiving hemodialysis. The uptake of ferric iron is considered to be much higher than that of ferrous iron. Case presentation The admitted patient was a 57-year-old Japanese woman with stage IIIB ovarian cancer who underwent primary debulking surgery and standard carboplatin–paclitaxel chemotherapy combined with bevacizumab, followed by niraparib (200 mg/day) maintenance therapy. The patient started oral SFC (100 mg/day) to treat niraparib-related anemia. However, she required two units of packed red blood cell transfusions three times within 3 months after starting niraparib treatment. The patient was diagnosed with niraparib-related anemia. The blood test results after 1 month from the start of niraparib treatment were as follows: red blood cells, 211 × 104/μL; hemoglobin, 7.0 g/dL; hematocrit, 20.8%; reticulocyte, 0.2%; platelet count, 18.0 × 104/μL. She was switched to oral ferric citrate hydrate with a dose of 500 mg per day and resumed niraparib treatment. She did not experience grade 3 niraparib-related hematological toxicity and achieved blood transfusion independence. Conclusions Ferric citrate hydrate may be a safe, effective, and well-tolerated oral drug for treating patients with niraparib-related anemia.https://doi.org/10.1186/s13256-022-03666-3AnemiaFerric citrate hydrateNiraparibOvarian cancer |
| spellingShingle | Hiroshi Kobayashi Yuki Yamada Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report Journal of Medical Case Reports Anemia Ferric citrate hydrate Niraparib Ovarian cancer |
| title | Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report |
| title_full | Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report |
| title_fullStr | Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report |
| title_full_unstemmed | Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report |
| title_short | Efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib: a case report |
| title_sort | efficacy of oral ferric citrate hydrate treatment for anemia caused by niraparib a case report |
| topic | Anemia Ferric citrate hydrate Niraparib Ovarian cancer |
| url | https://doi.org/10.1186/s13256-022-03666-3 |
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