Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma
The Fc fragment of IgG binding protein (FCGBP) has been confirmed to play an important role in various cancers. However, the specific role of FCGBP in hepatocellular carcinoma (HCC) remains undefined. Thus, in this study, the enrichment analyses (Gene Ontology, Kyoto Encyclopedia of Genes and Genome...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-07-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8586 |
| _version_ | 1827317527720493056 |
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| author | Yuhong Suo Chunyu Hou Guang Yang Hongfeng Yuan Lina Zhao Yufei Wang Ningning Zhang Xiaodong Zhang Wei Lu |
| author_facet | Yuhong Suo Chunyu Hou Guang Yang Hongfeng Yuan Lina Zhao Yufei Wang Ningning Zhang Xiaodong Zhang Wei Lu |
| author_sort | Yuhong Suo |
| collection | DOAJ |
| description | The Fc fragment of IgG binding protein (FCGBP) has been confirmed to play an important role in various cancers. However, the specific role of FCGBP in hepatocellular carcinoma (HCC) remains undefined. Thus, in this study, the enrichment analyses (Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis) of FCGBP in HCC and extensive bioinformatic analyses using data of clinicopathologic characteristics, genetic expression and alterations, and immune cell infiltration were perfomed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression of FCGBP in both HCC tissues and cell lines. The subsequent results confirmed thatFCGBP overexpression positively correlated with poor prognosis in patients with HCC. Additionally, FCGBP expression could effectively distinguish tumor tissues from normal tissues, which was verified by qRT-PCR. The result was further confirmed by using HCC cell lines. The time-dependent survival receiver operator characteristic curve exhibited the strong ability of FCGBP to predict survival in patients with HCC. Additionally, we revealed the strong relationship between FCGBP expression and a number of classic regulatory targets and classical oncogenic signaling pathways of tumors. Finally, FCGBP was involved in the regulation of immune infiltration in HCC. Therefore, FCGBP has potential value in the diagnosis, treatment, and prognosis of HCC and may be a potential biomarker or therapeutic target.
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| first_indexed | 2024-04-24T23:40:21Z |
| format | Article |
| id | doaj.art-a0f0ceaf29d84ac6a038f196957db37e |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:40:21Z |
| publishDate | 2023-07-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-a0f0ceaf29d84ac6a038f196957db37e2024-03-15T13:22:34ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-07-0123410.17305/bb.2022.8586Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinomaYuhong Suo0https://orcid.org/0000-0001-9382-1024Chunyu Hou1https://orcid.org/0000-0002-0624-4191Guang Yang2https://orcid.org/0000-0003-1305-4545Hongfeng Yuan3https://orcid.org/0000-0002-3772-5262Lina Zhao4https://orcid.org/0000-0002-4418-779XYufei Wang5https://orcid.org/0000-0001-9959-9903Ningning Zhang6Xiaodong Zhang7Wei Lu8Department of Hepatobiliary Oncology, Liver Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Hepatobiliary Oncology, Liver Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Hepatobiliary Oncology, Liver Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, ChinaThe Fc fragment of IgG binding protein (FCGBP) has been confirmed to play an important role in various cancers. However, the specific role of FCGBP in hepatocellular carcinoma (HCC) remains undefined. Thus, in this study, the enrichment analyses (Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis) of FCGBP in HCC and extensive bioinformatic analyses using data of clinicopathologic characteristics, genetic expression and alterations, and immune cell infiltration were perfomed. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression of FCGBP in both HCC tissues and cell lines. The subsequent results confirmed thatFCGBP overexpression positively correlated with poor prognosis in patients with HCC. Additionally, FCGBP expression could effectively distinguish tumor tissues from normal tissues, which was verified by qRT-PCR. The result was further confirmed by using HCC cell lines. The time-dependent survival receiver operator characteristic curve exhibited the strong ability of FCGBP to predict survival in patients with HCC. Additionally, we revealed the strong relationship between FCGBP expression and a number of classic regulatory targets and classical oncogenic signaling pathways of tumors. Finally, FCGBP was involved in the regulation of immune infiltration in HCC. Therefore, FCGBP has potential value in the diagnosis, treatment, and prognosis of HCC and may be a potential biomarker or therapeutic target. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8586Fc fragment of IgG binding protein (FCGBP)hepatocellular carcinoma (HCC)biomarkerGene Set Enrichment Analysis (GSEA)immune infiltration |
| spellingShingle | Yuhong Suo Chunyu Hou Guang Yang Hongfeng Yuan Lina Zhao Yufei Wang Ningning Zhang Xiaodong Zhang Wei Lu Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma Biomolecules & Biomedicine Fc fragment of IgG binding protein (FCGBP) hepatocellular carcinoma (HCC) biomarker Gene Set Enrichment Analysis (GSEA) immune infiltration |
| title | Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma |
| title_full | Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma |
| title_fullStr | Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma |
| title_full_unstemmed | Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma |
| title_short | Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma |
| title_sort | fc fragment of igg binding protein is correlated with immune infiltration levels in hepatocellular carcinoma |
| topic | Fc fragment of IgG binding protein (FCGBP) hepatocellular carcinoma (HCC) biomarker Gene Set Enrichment Analysis (GSEA) immune infiltration |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8586 |
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