Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction
Abstract Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal motility disorder with significant morbidity and mortality in pediatric patients. The diagnosis of CIPO is difficult, because it is clinically based on the symptoms and signs of bowel obstruction which are similar to the clin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-03-01
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| Series: | Orphanet Journal of Rare Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13023-017-0615-3 |
| _version_ | 1818265094992166912 |
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| author | Jun-Kai Yan Ke-Jun Zhou Jian-Hu Huang Qing-Qing Wu Tian Zhang Chao-Chen Wang Wei Cai |
| author_facet | Jun-Kai Yan Ke-Jun Zhou Jian-Hu Huang Qing-Qing Wu Tian Zhang Chao-Chen Wang Wei Cai |
| author_sort | Jun-Kai Yan |
| collection | DOAJ |
| description | Abstract Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal motility disorder with significant morbidity and mortality in pediatric patients. The diagnosis of CIPO is difficult, because it is clinically based on the symptoms and signs of bowel obstruction which are similar to the clinical manifestations of other gastrointestinal diseases like short bowel syndrome (SBS). Therefore, it is desirable to identify and establish new laboratory diagnostic markers for CIPO that are reliable and easily accessible. In our study we have identified the ratio of the urinary glutamine and glutamic acid as a promising biomarker for distinguishing suspected CIPO cases and simple SBS cases. The area under ROC curve was 0.83, at cutoff value = 7.04 with sensitivity of 65% and specificity of 92%. |
| first_indexed | 2024-12-12T19:45:21Z |
| format | Article |
| id | doaj.art-a0f557ecf04446ff9731a777a3cc6347 |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-12-12T19:45:21Z |
| publishDate | 2017-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-a0f557ecf04446ff9731a777a3cc63472022-12-22T00:14:06ZengBMCOrphanet Journal of Rare Diseases1750-11722017-03-011211410.1186/s13023-017-0615-3Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstructionJun-Kai Yan0Ke-Jun Zhou1Jian-Hu Huang2Qing-Qing Wu3Tian Zhang4Chao-Chen Wang5Wei Cai6Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Public Health, Aichi Medical UniversityDepartment of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal motility disorder with significant morbidity and mortality in pediatric patients. The diagnosis of CIPO is difficult, because it is clinically based on the symptoms and signs of bowel obstruction which are similar to the clinical manifestations of other gastrointestinal diseases like short bowel syndrome (SBS). Therefore, it is desirable to identify and establish new laboratory diagnostic markers for CIPO that are reliable and easily accessible. In our study we have identified the ratio of the urinary glutamine and glutamic acid as a promising biomarker for distinguishing suspected CIPO cases and simple SBS cases. The area under ROC curve was 0.83, at cutoff value = 7.04 with sensitivity of 65% and specificity of 92%.http://link.springer.com/article/10.1186/s13023-017-0615-3Chronic intestinal pseudo-obstructionShort bowel syndromeUrinary glutamine/glutamate ratiosBiomarker |
| spellingShingle | Jun-Kai Yan Ke-Jun Zhou Jian-Hu Huang Qing-Qing Wu Tian Zhang Chao-Chen Wang Wei Cai Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction Orphanet Journal of Rare Diseases Chronic intestinal pseudo-obstruction Short bowel syndrome Urinary glutamine/glutamate ratios Biomarker |
| title | Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction |
| title_full | Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction |
| title_fullStr | Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction |
| title_full_unstemmed | Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction |
| title_short | Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction |
| title_sort | urinary glutamine glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo obstruction |
| topic | Chronic intestinal pseudo-obstruction Short bowel syndrome Urinary glutamine/glutamate ratios Biomarker |
| url | http://link.springer.com/article/10.1186/s13023-017-0615-3 |
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