Animal Models of IgE Anaphylaxis
Allergies and atopy have emerged as significant public health concerns, with a progressively increasing incidence over the last two decades. Anaphylaxis is the most severe form of allergic reactions, characterized by a rapid onset and potentially fatal outcome, even in healthy individuals. Due to th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/7/931 |
| _version_ | 1797590247339458560 |
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| author | Aurélie Gouel-Chéron Alice Dejoux Emma Lamanna Pierre Bruhns |
| author_facet | Aurélie Gouel-Chéron Alice Dejoux Emma Lamanna Pierre Bruhns |
| author_sort | Aurélie Gouel-Chéron |
| collection | DOAJ |
| description | Allergies and atopy have emerged as significant public health concerns, with a progressively increasing incidence over the last two decades. Anaphylaxis is the most severe form of allergic reactions, characterized by a rapid onset and potentially fatal outcome, even in healthy individuals. Due to the unpredictable nature and potential lethality of anaphylaxis and the wide range of allergens involved, clinical studies in human patients have proven to be challenging. Diagnosis is further complicated by the lack of reliable laboratory biomarkers to confirm clinical suspicion. Thus, animal models have been developed to replicate human anaphylaxis and explore its pathophysiology. Whereas results obtained from animal models may not always be directly translatable to humans, they serve as a foundation for understanding the underlying mechanisms. Animal models are an essential tool for investigating new biomarkers that could be incorporated into the allergy workup for patients, as well as for the development of novel treatments. Two primary pathways have been described in animals and humans: classic, predominantly involving IgE and histamine, and alternative, reliant on IgG and the platelet-activating factor. This review will focus essentially on the former and aims to describe the most utilized IgE-mediated anaphylaxis animal models, including their respective advantages and limitations. |
| first_indexed | 2024-03-11T01:17:50Z |
| format | Article |
| id | doaj.art-a0f5d610e8ac42afaea6aa9c5d7b47fb |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T01:17:50Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a0f5d610e8ac42afaea6aa9c5d7b47fb2023-11-18T18:23:13ZengMDPI AGBiology2079-77372023-06-0112793110.3390/biology12070931Animal Models of IgE AnaphylaxisAurélie Gouel-Chéron0Alice Dejoux1Emma Lamanna2Pierre Bruhns3Université Paris Cité, 75010 Paris, FranceInstitut Pasteur, Université de Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, FranceInstitut Pasteur, Université de Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, FranceInstitut Pasteur, Université de Paris Cité, INSERM UMR1222, Antibodies in Therapy and Pathology, 75015 Paris, FranceAllergies and atopy have emerged as significant public health concerns, with a progressively increasing incidence over the last two decades. Anaphylaxis is the most severe form of allergic reactions, characterized by a rapid onset and potentially fatal outcome, even in healthy individuals. Due to the unpredictable nature and potential lethality of anaphylaxis and the wide range of allergens involved, clinical studies in human patients have proven to be challenging. Diagnosis is further complicated by the lack of reliable laboratory biomarkers to confirm clinical suspicion. Thus, animal models have been developed to replicate human anaphylaxis and explore its pathophysiology. Whereas results obtained from animal models may not always be directly translatable to humans, they serve as a foundation for understanding the underlying mechanisms. Animal models are an essential tool for investigating new biomarkers that could be incorporated into the allergy workup for patients, as well as for the development of novel treatments. Two primary pathways have been described in animals and humans: classic, predominantly involving IgE and histamine, and alternative, reliant on IgG and the platelet-activating factor. This review will focus essentially on the former and aims to describe the most utilized IgE-mediated anaphylaxis animal models, including their respective advantages and limitations.https://www.mdpi.com/2079-7737/12/7/931allergyanaphylaxisIgEanimal models |
| spellingShingle | Aurélie Gouel-Chéron Alice Dejoux Emma Lamanna Pierre Bruhns Animal Models of IgE Anaphylaxis Biology allergy anaphylaxis IgE animal models |
| title | Animal Models of IgE Anaphylaxis |
| title_full | Animal Models of IgE Anaphylaxis |
| title_fullStr | Animal Models of IgE Anaphylaxis |
| title_full_unstemmed | Animal Models of IgE Anaphylaxis |
| title_short | Animal Models of IgE Anaphylaxis |
| title_sort | animal models of ige anaphylaxis |
| topic | allergy anaphylaxis IgE animal models |
| url | https://www.mdpi.com/2079-7737/12/7/931 |
| work_keys_str_mv | AT aureliegouelcheron animalmodelsofigeanaphylaxis AT alicedejoux animalmodelsofigeanaphylaxis AT emmalamanna animalmodelsofigeanaphylaxis AT pierrebruhns animalmodelsofigeanaphylaxis |