Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-020-01455-4 |
| _version_ | 1818118194819235840 |
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| author | Xiaofan Lu Liyun Jiang Taige Chen Yang Wang Bing Zhang Yizhou Hong Jun Wang Fangrong Yan |
| author_facet | Xiaofan Lu Liyun Jiang Taige Chen Yang Wang Bing Zhang Yizhou Hong Jun Wang Fangrong Yan |
| author_sort | Xiaofan Lu |
| collection | DOAJ |
| description | Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. |
| first_indexed | 2024-12-11T04:50:26Z |
| format | Article |
| id | doaj.art-a0f64be88a3244b6aacda6e2def9f7fc |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-11T04:50:26Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-a0f64be88a3244b6aacda6e2def9f7fc2022-12-22T01:20:25ZengBMCRespiratory Research1465-993X2020-07-012111410.1186/s12931-020-01455-4Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19Xiaofan Lu0Liyun Jiang1Taige Chen2Yang Wang3Bing Zhang4Yizhou Hong5Jun Wang6Fangrong Yan7State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityMedical School of Nanjing UniversityDepartment of Radiology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Radiology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityDepartment of Intensive Care Medicine, The First Affiliated Hospital of Soochow UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityAbstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.http://link.springer.com/article/10.1186/s12931-020-01455-4COVID-19SpO2/FiO2Joint modelPrognostic marker |
| spellingShingle | Xiaofan Lu Liyun Jiang Taige Chen Yang Wang Bing Zhang Yizhou Hong Jun Wang Fangrong Yan Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 Respiratory Research COVID-19 SpO2/FiO2 Joint model Prognostic marker |
| title | Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 |
| title_full | Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 |
| title_fullStr | Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 |
| title_full_unstemmed | Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 |
| title_short | Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 |
| title_sort | continuously available ratio of spo2 fio2 serves as a noninvasive prognostic marker for intensive care patients with covid 19 |
| topic | COVID-19 SpO2/FiO2 Joint model Prognostic marker |
| url | http://link.springer.com/article/10.1186/s12931-020-01455-4 |
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