Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study
Background: The United Nations high-level meeting (UNHLM) pledged to enroll 30 million in tuberculosis preventive treatment (TPT) by 2022, necessitating TPT expansion to all at tuberculosis (TB) risk. We assessed the uptake and completion of a 12-dose, weekly isoniazid–rifapentine (3HP) TPT regimen....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/9/1/4 |
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| author | Md. Toufiq Rahman Farzana Hossain Rupali Sisir Banu Md. Shamiul Islam Shamsher Alam Abu Jamil Faisel Hamid Salim Oscar Cordon Pedro Suarez Hamidah Hussain Tapash Roy |
| author_facet | Md. Toufiq Rahman Farzana Hossain Rupali Sisir Banu Md. Shamiul Islam Shamsher Alam Abu Jamil Faisel Hamid Salim Oscar Cordon Pedro Suarez Hamidah Hussain Tapash Roy |
| author_sort | Md. Toufiq Rahman |
| collection | DOAJ |
| description | Background: The United Nations high-level meeting (UNHLM) pledged to enroll 30 million in tuberculosis preventive treatment (TPT) by 2022, necessitating TPT expansion to all at tuberculosis (TB) risk. We assessed the uptake and completion of a 12-dose, weekly isoniazid–rifapentine (3HP) TPT regimen. Methods: Between February 2018 and March 2019 in Dhaka, community-based TPT using 3HP targeted household contacts of 883 confirmed drug-sensitive pulmonary TB patients. Adhering to World Health Organization guidelines, contacts underwent active TB screening before TPT initiation. Results: Of 3193 contacts who were advised health facility visits for screening, 67% (<i>n</i> = 2149) complied. Among these, 1804 (84%) received chest X-rays. Active TB was diagnosed in 39 (2%) contacts; they commenced TB treatment. Over 97% of 1216 contacts began TPT, with completion rates higher among females, those with more education and income, non-slum residents, and those without 3HP-related adverse events. Adverse events, mainly mild, occurred in 5% of participants. Conclusions: The 3HP regimen, with its short duration, self-administered option, and minimal side effects, achieved satisfactory completion rates. A community-focused TPT approach is feasible, scalable nationally, and aligns with UNHLM targets. |
| first_indexed | 2024-03-08T10:33:38Z |
| format | Article |
| id | doaj.art-a0f6f3d3b98a423dafeb0c6f3abe9be9 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-08T10:33:38Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-a0f6f3d3b98a423dafeb0c6f3abe9be92024-01-26T18:42:41ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-12-0191410.3390/tropicalmed9010004Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation StudyMd. Toufiq Rahman0Farzana Hossain1Rupali Sisir Banu2Md. Shamiul Islam3Shamsher Alam4Abu Jamil Faisel5Hamid Salim6Oscar Cordon7Pedro Suarez8Hamidah Hussain9Tapash Roy10Interactive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, BangladeshInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, BangladeshNational Tuberculosis Control Program, Directorate General of Health Services, Ministry of Health and Family Welfare, Dhaka 1212, BangladeshDirectorate General of Health Services, Ministry of Health and Family Welfare, Dhaka 1212, BangladeshInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, BangladeshInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, BangladeshNational Tuberculosis Control Program, Directorate General of Health Services, Ministry of Health and Family Welfare, Dhaka 1212, BangladeshChallenge TB Project, Management Sciences for Health, Dhaka 1212, BangladeshManagement Sciences for Health, Arlington, TX 22203, USAIRD Global, Singapore 048581, SingaporeInteractive Research and Development, Bangladesh (IRD Bangladesh), Dhaka 1212, BangladeshBackground: The United Nations high-level meeting (UNHLM) pledged to enroll 30 million in tuberculosis preventive treatment (TPT) by 2022, necessitating TPT expansion to all at tuberculosis (TB) risk. We assessed the uptake and completion of a 12-dose, weekly isoniazid–rifapentine (3HP) TPT regimen. Methods: Between February 2018 and March 2019 in Dhaka, community-based TPT using 3HP targeted household contacts of 883 confirmed drug-sensitive pulmonary TB patients. Adhering to World Health Organization guidelines, contacts underwent active TB screening before TPT initiation. Results: Of 3193 contacts who were advised health facility visits for screening, 67% (<i>n</i> = 2149) complied. Among these, 1804 (84%) received chest X-rays. Active TB was diagnosed in 39 (2%) contacts; they commenced TB treatment. Over 97% of 1216 contacts began TPT, with completion rates higher among females, those with more education and income, non-slum residents, and those without 3HP-related adverse events. Adverse events, mainly mild, occurred in 5% of participants. Conclusions: The 3HP regimen, with its short duration, self-administered option, and minimal side effects, achieved satisfactory completion rates. A community-focused TPT approach is feasible, scalable nationally, and aligns with UNHLM targets.https://www.mdpi.com/2414-6366/9/1/4TB preventive treatmentUNHLMEnd TBTPT3HPBangladesh |
| spellingShingle | Md. Toufiq Rahman Farzana Hossain Rupali Sisir Banu Md. Shamiul Islam Shamsher Alam Abu Jamil Faisel Hamid Salim Oscar Cordon Pedro Suarez Hamidah Hussain Tapash Roy Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study Tropical Medicine and Infectious Disease TB preventive treatment UNHLM End TB TPT 3HP Bangladesh |
| title | Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study |
| title_full | Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study |
| title_fullStr | Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study |
| title_full_unstemmed | Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study |
| title_short | Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study |
| title_sort | uptake and completion of tuberculosis preventive treatment using 12 dose weekly isoniazid rifapentine regimen in bangladesh a community based implementation study |
| topic | TB preventive treatment UNHLM End TB TPT 3HP Bangladesh |
| url | https://www.mdpi.com/2414-6366/9/1/4 |
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