Increasing Dosage of Leucovorin Results in Pharmacokinetic and Gene Expression Differences When Administered as Two-Hour Infusion or Bolus Injection to Patients with Colon Cancer

Increasing Dosage of Leucovorin Results in Pharmacokinetic and Gene Expression Differences When Administered as Two-Hour Infusion or Bolus Injection to Patients with Colon Cancer

The combination of 5-fluorouracil (5-FU) and leucovorin (LV) forms the chemotherapy backbone for patients with colorectal cancer. However, the LV administration is often standardized and not based on robust scientific data. To address these issues, a randomized pharmacokinetics study was performed i...

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Bibliographic Details
Main Authors: Helena Taflin, Elisabeth Odin, Göran Carlsson, Bengt Gustavsson, Yvonne Wettergren, Elinor Bexe Lindskog
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
pharmacokinetics
leucovorin
two-hour infusion
bolus injection
colon cancer
gene expression
Online Access:https://www.mdpi.com/2072-6694/15/1/258

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