Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq
Indications of cell maturing including telomere length and mitochondrial work, just as oxidative pressure and incendiary markers affect one another and structure a complicated organization, which all influenced in age related sicknesses, for example, diabetes mellitus. For this cause, this...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2022-01-01
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| Series: | Kurdistan Journal of Applied Research |
| Subjects: | |
| Online Access: | https://www.kjar.spu.edu.iq/index.php/kjar/article/view/698 |
| _version_ | 1797193729157627904 |
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| author | Kaniaw Rafat Khafar Dr. Esmail S Kakey |
| author_facet | Kaniaw Rafat Khafar Dr. Esmail S Kakey |
| author_sort | Kaniaw Rafat Khafar |
| collection | DOAJ |
| description |
Indications of cell maturing including telomere length and mitochondrial work, just as oxidative pressure and incendiary markers affect one another and structure a complicated organization, which all influenced in age related sicknesses, for example, diabetes mellitus. For this cause, this current investigation was designed to study and compare of some oxidative and molecular markers in healthy aged and diabetic aged men older adults. The study design was the setting of a medium private laboratory with participants being common people, which was classified into three groups according to age and health complication, control young, healthy aged, and diabetic aged groups. Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). The findings highlighted that oxidative and molecular markers have significant changes with ageing and high changes significantly associated with diabetes mellitus of aged group. In conclusion, various oxidative stress, cell and mitochondrial biomarkers have been affected by normal ageing and the effects of ageing were complicated significantly in diabetic aged elderly.
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| first_indexed | 2024-03-07T15:26:58Z |
| format | Article |
| id | doaj.art-a0f7a595ee4e47ab84bf1b513972e610 |
| institution | Directory Open Access Journal |
| issn | 2411-7684 2411-7706 |
| language | English |
| last_indexed | 2024-04-24T05:45:01Z |
| publishDate | 2022-01-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj.art-a0f7a595ee4e47ab84bf1b513972e6102024-04-23T17:20:29ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062022-01-01Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-IraqKaniaw Rafat Khafar0Dr. Esmail S Kakey1Nursing department, Medicine Technical college, Sulaimani Polytechnic University, SulaimaniBiology Department Faculty of science and health Koya University Koya KOY45, Kurdistan Region – F.R. Iraq Indications of cell maturing including telomere length and mitochondrial work, just as oxidative pressure and incendiary markers affect one another and structure a complicated organization, which all influenced in age related sicknesses, for example, diabetes mellitus. For this cause, this current investigation was designed to study and compare of some oxidative and molecular markers in healthy aged and diabetic aged men older adults. The study design was the setting of a medium private laboratory with participants being common people, which was classified into three groups according to age and health complication, control young, healthy aged, and diabetic aged groups. Blood sera was obtained for oxidative status including catalase (CAT), superoxide dismutase (SOD), Total antioxidant capacity (T-AOC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)) and molecular markers (including telomere length (T/S) and mitochondrial DNA copy number (mtDNA)). The findings highlighted that oxidative and molecular markers have significant changes with ageing and high changes significantly associated with diabetes mellitus of aged group. In conclusion, various oxidative stress, cell and mitochondrial biomarkers have been affected by normal ageing and the effects of ageing were complicated significantly in diabetic aged elderly. https://www.kjar.spu.edu.iq/index.php/kjar/article/view/698Oxidative stress markers, molecular markers, diabetic mellitus adults, aging adults, man |
| spellingShingle | Kaniaw Rafat Khafar Dr. Esmail S Kakey Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq Kurdistan Journal of Applied Research Oxidative stress markers, molecular markers, diabetic mellitus adults, aging adults, man |
| title | Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq |
| title_full | Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq |
| title_fullStr | Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq |
| title_full_unstemmed | Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq |
| title_short | Implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in Kurdistan region-Iraq |
| title_sort | implication of diabetes mellitus in telomere length and alteration in some age related cell senescence markers of aged men in kurdistan region iraq |
| topic | Oxidative stress markers, molecular markers, diabetic mellitus adults, aging adults, man |
| url | https://www.kjar.spu.edu.iq/index.php/kjar/article/view/698 |
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