Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity
Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically uni...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/52696 |
| _version_ | 1811199558250659840 |
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| author | Gurmeet Kaur A Maxwell Burroughs Lakshminarayan M Iyer L Aravind |
| author_facet | Gurmeet Kaur A Maxwell Burroughs Lakshminarayan M Iyer L Aravind |
| author_sort | Gurmeet Kaur |
| collection | DOAJ |
| description | Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically unified, remarkable biological conflict systems preponderantly present in multicellular prokaryotes. These combine thresholding mechanisms utilizing NTPase chaperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effectors, which vary either by using a reverse transcriptase-dependent diversity-generating system or through a system of acquisition of diverse protein modules, typically in inactive form, from various cellular subsystems. Conciliant lines of evidence indicate their deployment against invasive entities, like viruses, to limit their spread in multicellular/social contexts via physical containment, dominant-negative interactions or apoptosis. These findings argue for both a similar operational ‘grammar’ and shared protein domains in the sensing and limiting of infections during the multiple emergences of multicellularity. |
| first_indexed | 2024-04-12T01:49:38Z |
| format | Article |
| id | doaj.art-a0f90e4cb6064018b52010f1844631b0 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:49:38Z |
| publishDate | 2020-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a0f90e4cb6064018b52010f1844631b02022-12-22T03:52:58ZengeLife Sciences Publications LtdeLife2050-084X2020-02-01910.7554/eLife.52696Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularityGurmeet Kaur0A Maxwell Burroughs1https://orcid.org/0000-0002-2229-8771Lakshminarayan M Iyer2L Aravind3https://orcid.org/0000-0003-0771-253XComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United StatesComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United StatesComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United StatesComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United StatesSocial cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically unified, remarkable biological conflict systems preponderantly present in multicellular prokaryotes. These combine thresholding mechanisms utilizing NTPase chaperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effectors, which vary either by using a reverse transcriptase-dependent diversity-generating system or through a system of acquisition of diverse protein modules, typically in inactive form, from various cellular subsystems. Conciliant lines of evidence indicate their deployment against invasive entities, like viruses, to limit their spread in multicellular/social contexts via physical containment, dominant-negative interactions or apoptosis. These findings argue for both a similar operational ‘grammar’ and shared protein domains in the sensing and limiting of infections during the multiple emergences of multicellularity.https://elifesciences.org/articles/52696multicellular prokaryoteschaperonesAAA+ ATPaseGTPaseapoptosisDEATH domain |
| spellingShingle | Gurmeet Kaur A Maxwell Burroughs Lakshminarayan M Iyer L Aravind Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity eLife multicellular prokaryotes chaperones AAA+ ATPase GTPase apoptosis DEATH domain |
| title | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
| title_full | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
| title_fullStr | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
| title_full_unstemmed | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
| title_short | Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity |
| title_sort | highly regulated diversifying ntp dependent biological conflict systems with implications for the emergence of multicellularity |
| topic | multicellular prokaryotes chaperones AAA+ ATPase GTPase apoptosis DEATH domain |
| url | https://elifesciences.org/articles/52696 |
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