Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells

Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells

Abstract Background As the precursors of sperm and eggs, human primordial germ cells (hPGCs) emerge as early as weeks 2 to 3 of post-implantation development. Recently, robust hPGC induction models have been established in vitro with different protocols, but global 5mC/5hmC epigenetic reprogramming...

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Bibliographic Details
Main Authors: Zili Li, Fang Fang, Qian Zhao, Honggang Li, Chengliang Xiong
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Stem Cell Research & Therapy
Subjects:
Embryonic stem cells
Primordial germ cells
Vitamin C
Epigenetic
Online Access:http://link.springer.com/article/10.1186/s13287-019-1427-2

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