Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis
Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone defects. Herein we combine β-TCP with 6 mol% magnesium-doped calcium silicate (Mg6) at three different ratios (TCP, TCP+15 %Mg6, TCP+85 %Mg6) to find an appropriate ratio which...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Engineered Regeneration |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666138123000518 |
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| author | Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng Xupeng Chai Cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru Gou Zhaoming Ye |
| author_facet | Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng Xupeng Chai Cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru Gou Zhaoming Ye |
| author_sort | Lijun Xie |
| collection | DOAJ |
| description | Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone defects. Herein we combine β-TCP with 6 mol% magnesium-doped calcium silicate (Mg6) at three different ratios (TCP, TCP+15 %Mg6, TCP+85 %Mg6) to find an appropriate ratio which can exert considerable influence on bone regeneration. In this study, the bioceramic scaffolds were assessed for mechanical strength, bioactive ion release, biocompatibility, and osteogenic capacity through in vitro testing. Additionally, the potential for promoting bone regeneration was investigated through in vivo implantation of porous tube-like scaffolds. The results showed that the compressive strength increased with the augmentation of Mg6 component. Especially the compressive strength of the TCP+85 %Mg6 group reached 38.1 ± 3.8 MPa, three times that of the other two groups. Furthermore, extensive in vivo investigations revealed that the TCP+85 %Mg6 bioceramic scaffolds were particularly beneficial for the osteogenic capacity of critical-sized femoral defects (20 mm in length). Altogether, magnesium doping in bioceramic implants is a promising strategy to provide stronger mechanical support and enhance osteogenesis to accelerate the repair of large defects. |
| first_indexed | 2024-03-08T05:14:23Z |
| format | Article |
| id | doaj.art-a0fc65fe7b1c4cd4a2448ca5e8f7adb5 |
| institution | Directory Open Access Journal |
| issn | 2666-1381 |
| language | English |
| last_indexed | 2024-03-08T05:14:23Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Engineered Regeneration |
| spelling | doaj.art-a0fc65fe7b1c4cd4a2448ca5e8f7adb52024-02-07T04:45:47ZengKeAi Communications Co., Ltd.Engineered Regeneration2666-13812024-03-0151110Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesisLijun Xie0Jiahao Zhang1Hangxiang Sun2Zehao Chen3Wangsiyuan Teng4Xupeng Chai5Cong Wang6Xianyan Yang7Yifan Li8Sanzhong Xu9Zhongru Gou10Zhaoming Ye11Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR ChinaBio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, PR ChinaDepartment of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, PR ChinaDepartment of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, PR ChinaBio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, PR China; Corresponding authors at: Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China.Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou 310000, PR China; Corresponding authors at: Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, PR China.Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone defects. Herein we combine β-TCP with 6 mol% magnesium-doped calcium silicate (Mg6) at three different ratios (TCP, TCP+15 %Mg6, TCP+85 %Mg6) to find an appropriate ratio which can exert considerable influence on bone regeneration. In this study, the bioceramic scaffolds were assessed for mechanical strength, bioactive ion release, biocompatibility, and osteogenic capacity through in vitro testing. Additionally, the potential for promoting bone regeneration was investigated through in vivo implantation of porous tube-like scaffolds. The results showed that the compressive strength increased with the augmentation of Mg6 component. Especially the compressive strength of the TCP+85 %Mg6 group reached 38.1 ± 3.8 MPa, three times that of the other two groups. Furthermore, extensive in vivo investigations revealed that the TCP+85 %Mg6 bioceramic scaffolds were particularly beneficial for the osteogenic capacity of critical-sized femoral defects (20 mm in length). Altogether, magnesium doping in bioceramic implants is a promising strategy to provide stronger mechanical support and enhance osteogenesis to accelerate the repair of large defects.http://www.sciencedirect.com/science/article/pii/S2666138123000518Bioceramic tubesMg-doped calcium silicatePorous structural stabilityLarge segmental bone defectsDigital light processing |
| spellingShingle | Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng Xupeng Chai Cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru Gou Zhaoming Ye Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis Engineered Regeneration Bioceramic tubes Mg-doped calcium silicate Porous structural stability Large segmental bone defects Digital light processing |
| title | Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis |
| title_full | Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis |
| title_fullStr | Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis |
| title_full_unstemmed | Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis |
| title_short | Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis |
| title_sort | mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long term structurally stability and promoting osteogenesis |
| topic | Bioceramic tubes Mg-doped calcium silicate Porous structural stability Large segmental bone defects Digital light processing |
| url | http://www.sciencedirect.com/science/article/pii/S2666138123000518 |
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