Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study
Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) gly...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.633214/full |
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| author | Ema Prenc Ema Prenc Drazen Pulanic Drazen Pulanic Maja Pucic-Bakovic Ivo Ugrina Ivo Ugrina Lana Desnica Milan Milosevic Milan Milosevic Filip Pirsl Sandra Mitchell Jeremy Rose Radovan Vrhovac Radovan Vrhovac Damir Nemet Damir Nemet Gordan Lauc Steven Z. Pavletic |
| author_facet | Ema Prenc Ema Prenc Drazen Pulanic Drazen Pulanic Maja Pucic-Bakovic Ivo Ugrina Ivo Ugrina Lana Desnica Milan Milosevic Milan Milosevic Filip Pirsl Sandra Mitchell Jeremy Rose Radovan Vrhovac Radovan Vrhovac Damir Nemet Damir Nemet Gordan Lauc Steven Z. Pavletic |
| author_sort | Ema Prenc |
| collection | DOAJ |
| description | Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) glycoprotein is the main effector molecule of the humoral immune response. Changes in IgG glycosylation are associated with a number of autoimmune diseases. IgG glycosylation analysis was done by the means of liquid chromatography in the National Institutes of Health (NIH) cohort of 213 cGvHD patients. The results showed statistically significant differences with regards to cGvHD NIH joint/fascia and skin score, disease activity and intensity of systemic immunosuppression. ROC analysis confirmed that IgG glycosylation increases specificity and sensitivity of models using laboratory parameters and markers of inflammation associated with cGvHD (eosinophil count, complement components C3 and C4 and inflammation markers: albumin, CRP and thrombocyte count). This research shows that IgG glycosylation may play a significant role in cGvHD pathology. Further research could contribute to the understanding of the disease biology and lead to the clinical biomarker development to allow personalized approaches to chronic GvHD therapy. |
| first_indexed | 2024-12-22T01:13:33Z |
| format | Article |
| id | doaj.art-a0fd4b0df3fd4e1889c4d135f7891ce1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T01:13:33Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a0fd4b0df3fd4e1889c4d135f7891ce12022-12-21T18:43:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.633214633214Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort StudyEma Prenc0Ema Prenc1Drazen Pulanic2Drazen Pulanic3Maja Pucic-Bakovic4Ivo Ugrina5Ivo Ugrina6Lana Desnica7Milan Milosevic8Milan Milosevic9Filip Pirsl10Sandra Mitchell11Jeremy Rose12Radovan Vrhovac13Radovan Vrhovac14Damir Nemet15Damir Nemet16Gordan Lauc17Steven Z. Pavletic18Fidelta Ltd., Translational Research and Alliances, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb, CroatiaGenos Ltd., Zagreb, CroatiaGenos Ltd., Zagreb, CroatiaFaculty of Science, University of Split, Split, CroatiaDepartment of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Environmental and Occupational Health and Sports, Andrija Stampar Teaching Institute of Public Health, Zagreb, CroatiaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesSchool of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb, CroatiaGenos Ltd., Zagreb, CroatiaCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesChronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) glycoprotein is the main effector molecule of the humoral immune response. Changes in IgG glycosylation are associated with a number of autoimmune diseases. IgG glycosylation analysis was done by the means of liquid chromatography in the National Institutes of Health (NIH) cohort of 213 cGvHD patients. The results showed statistically significant differences with regards to cGvHD NIH joint/fascia and skin score, disease activity and intensity of systemic immunosuppression. ROC analysis confirmed that IgG glycosylation increases specificity and sensitivity of models using laboratory parameters and markers of inflammation associated with cGvHD (eosinophil count, complement components C3 and C4 and inflammation markers: albumin, CRP and thrombocyte count). This research shows that IgG glycosylation may play a significant role in cGvHD pathology. Further research could contribute to the understanding of the disease biology and lead to the clinical biomarker development to allow personalized approaches to chronic GvHD therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2021.633214/fullallogeneic hematopoietic stem cell transplantationchronic graft-versus-host diseaseimmunoglobulin Gglycansbiomarker |
| spellingShingle | Ema Prenc Ema Prenc Drazen Pulanic Drazen Pulanic Maja Pucic-Bakovic Ivo Ugrina Ivo Ugrina Lana Desnica Milan Milosevic Milan Milosevic Filip Pirsl Sandra Mitchell Jeremy Rose Radovan Vrhovac Radovan Vrhovac Damir Nemet Damir Nemet Gordan Lauc Steven Z. Pavletic Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study Frontiers in Immunology allogeneic hematopoietic stem cell transplantation chronic graft-versus-host disease immunoglobulin G glycans biomarker |
| title | Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study |
| title_full | Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study |
| title_fullStr | Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study |
| title_full_unstemmed | Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study |
| title_short | Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study |
| title_sort | significant associations of igg glycan structures with chronic graft versus host disease manifestations results of the cross sectional nih cohort study |
| topic | allogeneic hematopoietic stem cell transplantation chronic graft-versus-host disease immunoglobulin G glycans biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.633214/full |
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