Identifying fibrogenic cells following salivary gland obstructive injury

Identifying fibrogenic cells following salivary gland obstructive injury

Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren’s Disease, and other causes; however, it is unclear which stromal cells an...

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Bibliographic Details
Main Authors: Amber L. Altrieth, Kevin J. O’Keefe, Victoria A. Gellatly, Joey R. Tavarez, Sage M. Feminella, Nicholas L. Moskwa, Carmalena V. Cordi, Judy C. Turrieta, Deirdre A. Nelson, Melinda Larsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
extracellular matrix (ECM)
salivary gland
Gli1
fibrosis
platelet derived growth factor receptor (PDGFR)
collagen
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1190386/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1190386/full

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