Synergistic Activity and Mechanism of Sanguinarine with Polymyxin B against Gram-Negative Bacterial Infections

Synergistic Activity and Mechanism of Sanguinarine with Polymyxin B against Gram-Negative Bacterial Infections

Compounds that potentiate the activity of clinically available antibiotics provide a complementary solution, except for developing novel antibiotics for the rapid emergence of multidrug-resistant Gram-negative bacteria (GNB). We sought to identify compounds potentiating polymyxin B (PMB), a traditio...

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Bibliographic Details
Main Authors: Luyao Qiao, Yu Zhang, Ying Chen, Xiangyin Chi, Jinwen Ding, Hongjuan Zhang, Yanxing Han, Bo Zhang, Jiandong Jiang, Yuan Lin
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
Gram-negative bacteria
polymyxin B
sanguinarine
combinations
bacterial membrane
Online Access:https://www.mdpi.com/1999-4923/16/1/70

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