Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study
Transcranial alternating current stimulation (tACS) is an emerging non-invasive neuromodulation technique, which could be potentially applied to enhance stroke rehabilitation. In this study, we aimed to characterize the frequency-specific effects of tACS in chronic stroke. Therefore, concurrent tACS...
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| Format: | Article |
| Language: | English |
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IEEE
2022-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
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| Online Access: | https://ieeexplore.ieee.org/document/9718333/ |
| _version_ | 1797805171344932864 |
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| author | Kai Yuan Cheng Chen Wu-Tao Lou Ahsan Khan Eden Chun-Hang Ti Cathy Choi-Yin Lau Xin Wang Winnie Chiu-Wing Chu Raymond Kai-Yu Tong |
| author_facet | Kai Yuan Cheng Chen Wu-Tao Lou Ahsan Khan Eden Chun-Hang Ti Cathy Choi-Yin Lau Xin Wang Winnie Chiu-Wing Chu Raymond Kai-Yu Tong |
| author_sort | Kai Yuan |
| collection | DOAJ |
| description | Transcranial alternating current stimulation (tACS) is an emerging non-invasive neuromodulation technique, which could be potentially applied to enhance stroke rehabilitation. In this study, we aimed to characterize the frequency-specific effects of tACS in chronic stroke. Therefore, concurrent tACS and functional magnetic resonance imaging (fMRI) were conducted in 13 chronic stroke individuals. Resting-state and task-based fMRI were collected for each subject under different frequencies (10 Hz, 20 Hz, Sham). Task-based fMRI showed that increased activation was found in the ipsilesional precentral area during paretic hand movements after 10 Hz tACS, while increased activation was found in the contralesional precentral area during non-paretic hand movements after both 10 and 20 Hz tACS. Resting-state seed-based functional connectivity (FC) analysis showed that 10 Hz tACS mainly modulated FC within motor-related regions, while 20 Hz tACS also modulated regions beyond the motor-related areas. Graph theory analysis further demonstrated the functional interaction modulated by tACS in the whole-brain level. Taken together, our results showed that tACS might exhibit frequency-specific modulation in chronic stroke. 20 Hz tACS facilitates the functional interaction between the sensorimotor regions and brain regions involved in executive control, while 10 Hz and sham tACS has limited effect on motor-related brain activity. Our results reveal the neural response process under external current stimulation, providing new insight into the neuromodulation mechanism of tACS in a lesioned brain. |
| first_indexed | 2024-03-13T05:47:06Z |
| format | Article |
| id | doaj.art-a100f82103de4311b97bb9f187427960 |
| institution | Directory Open Access Journal |
| issn | 1558-0210 |
| language | English |
| last_indexed | 2024-03-13T05:47:06Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj.art-a100f82103de4311b97bb9f1874279602023-06-13T20:08:10ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1558-02102022-01-013045546410.1109/TNSRE.2022.31533539718333Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI StudyKai Yuan0https://orcid.org/0000-0001-6105-4772Cheng Chen1Wu-Tao Lou2https://orcid.org/0000-0002-6844-2847Ahsan Khan3Eden Chun-Hang Ti4Cathy Choi-Yin Lau5Xin Wang6https://orcid.org/0000-0003-2602-3967Winnie Chiu-Wing Chu7https://orcid.org/0000-0003-4962-4132Raymond Kai-Yu Tong8https://orcid.org/0000-0003-4375-653XDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong KongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong KongTranscranial alternating current stimulation (tACS) is an emerging non-invasive neuromodulation technique, which could be potentially applied to enhance stroke rehabilitation. In this study, we aimed to characterize the frequency-specific effects of tACS in chronic stroke. Therefore, concurrent tACS and functional magnetic resonance imaging (fMRI) were conducted in 13 chronic stroke individuals. Resting-state and task-based fMRI were collected for each subject under different frequencies (10 Hz, 20 Hz, Sham). Task-based fMRI showed that increased activation was found in the ipsilesional precentral area during paretic hand movements after 10 Hz tACS, while increased activation was found in the contralesional precentral area during non-paretic hand movements after both 10 and 20 Hz tACS. Resting-state seed-based functional connectivity (FC) analysis showed that 10 Hz tACS mainly modulated FC within motor-related regions, while 20 Hz tACS also modulated regions beyond the motor-related areas. Graph theory analysis further demonstrated the functional interaction modulated by tACS in the whole-brain level. Taken together, our results showed that tACS might exhibit frequency-specific modulation in chronic stroke. 20 Hz tACS facilitates the functional interaction between the sensorimotor regions and brain regions involved in executive control, while 10 Hz and sham tACS has limited effect on motor-related brain activity. Our results reveal the neural response process under external current stimulation, providing new insight into the neuromodulation mechanism of tACS in a lesioned brain.https://ieeexplore.ieee.org/document/9718333/Transcranial alternating current stimulationstrokefunctional magnetic resonance imagingfunctional connectivitygraph theory |
| spellingShingle | Kai Yuan Cheng Chen Wu-Tao Lou Ahsan Khan Eden Chun-Hang Ti Cathy Choi-Yin Lau Xin Wang Winnie Chiu-Wing Chu Raymond Kai-Yu Tong Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study IEEE Transactions on Neural Systems and Rehabilitation Engineering Transcranial alternating current stimulation stroke functional magnetic resonance imaging functional connectivity graph theory |
| title | Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study |
| title_full | Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study |
| title_fullStr | Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study |
| title_full_unstemmed | Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study |
| title_short | Differential Effects of 10 and 20 Hz Brain Stimulation in Chronic Stroke: A tACS-fMRI Study |
| title_sort | differential effects of 10 and 20 hz brain stimulation in chronic stroke a tacs fmri study |
| topic | Transcranial alternating current stimulation stroke functional magnetic resonance imaging functional connectivity graph theory |
| url | https://ieeexplore.ieee.org/document/9718333/ |
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