Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity
Abstract Background Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accou...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0546-x |
| _version_ | 1818243374622179328 |
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| author | Jonathan R Weir-McCall Faisel Khan Deirdre B Cassidy Arsh Thakur Jennifer Summersgill Shona Z Matthew Fiona Adams Fiona Dove Stephen J Gandy Helen M Colhoun Jill JF Belch J Graeme Houston |
| author_facet | Jonathan R Weir-McCall Faisel Khan Deirdre B Cassidy Arsh Thakur Jennifer Summersgill Shona Z Matthew Fiona Adams Fiona Dove Stephen J Gandy Helen M Colhoun Jill JF Belch J Graeme Houston |
| author_sort | Jonathan R Weir-McCall |
| collection | DOAJ |
| description | Abstract Background Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements. Methods One hundred fourteen study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n = 23), T2DM without CVD (n = 41), CVD without T2DM (n = 25) and a control group (n = 25). All participants underwent cf.-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf.-PWVEXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf.-PWVEXT to give a cf.-PWVMRA. Results Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = −85.4 ± 54.0 mm,p < 0.001). MRI-PWV was significantly lower than cf.-PWVEXT (MRI-PWV = 8.1 ± 2.9 vs. cf.-PWVEXT = 10.9 ± 2.7 ms−1,p < 0.001). When cf.-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV = 8.1 ± 2.9 ms−1 vs. cf.-PWVMRA 9.1 ± 2.1 ms−1, mean diff = −0.96 ± 2.52 ms−1,p = 0.001). Recalculation of the PWV increased correlation with age and pulse pressure. Conclusion Differences in cf.-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries. |
| first_indexed | 2024-12-12T14:00:07Z |
| format | Article |
| id | doaj.art-a10199071a8f4ccf9a0a527355facf51 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-12T14:00:07Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-a10199071a8f4ccf9a0a527355facf512022-12-22T00:22:21ZengBMCBMC Cardiovascular Disorders1471-22612017-05-011711910.1186/s12872-017-0546-xEffects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocityJonathan R Weir-McCall0Faisel Khan1Deirdre B Cassidy2Arsh Thakur3Jennifer Summersgill4Shona Z Matthew5Fiona Adams6Fiona Dove7Stephen J Gandy8Helen M Colhoun9Jill JF Belch10J Graeme Houston11Division of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeNHS Tayside Medical Physics, Ninewells HospitalCentre for Genomic and Experimental Medicine, The University of Edinburgh, Western General HospitalDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeDivision of Molecular and Clinical Medicine, Medical Research Institute, University of DundeeAbstract Background Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements. Methods One hundred fourteen study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n = 23), T2DM without CVD (n = 41), CVD without T2DM (n = 25) and a control group (n = 25). All participants underwent cf.-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf.-PWVEXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf.-PWVEXT to give a cf.-PWVMRA. Results Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = −85.4 ± 54.0 mm,p < 0.001). MRI-PWV was significantly lower than cf.-PWVEXT (MRI-PWV = 8.1 ± 2.9 vs. cf.-PWVEXT = 10.9 ± 2.7 ms−1,p < 0.001). When cf.-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV = 8.1 ± 2.9 ms−1 vs. cf.-PWVMRA 9.1 ± 2.1 ms−1, mean diff = −0.96 ± 2.52 ms−1,p = 0.001). Recalculation of the PWV increased correlation with age and pulse pressure. Conclusion Differences in cf.-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries.http://link.springer.com/article/10.1186/s12872-017-0546-xArteriosclerosisMRIPWVDiabetesCardiovascular |
| spellingShingle | Jonathan R Weir-McCall Faisel Khan Deirdre B Cassidy Arsh Thakur Jennifer Summersgill Shona Z Matthew Fiona Adams Fiona Dove Stephen J Gandy Helen M Colhoun Jill JF Belch J Graeme Houston Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity BMC Cardiovascular Disorders Arteriosclerosis MRI PWV Diabetes Cardiovascular |
| title | Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity |
| title_full | Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity |
| title_fullStr | Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity |
| title_full_unstemmed | Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity |
| title_short | Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity |
| title_sort | effects of inaccuracies in arterial path length measurement on differences in mri and tonometry measured pulse wave velocity |
| topic | Arteriosclerosis MRI PWV Diabetes Cardiovascular |
| url | http://link.springer.com/article/10.1186/s12872-017-0546-x |
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