Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i>
Caffeine and ethanol are among the most widely available and commonly consumed psychoactive substances. Both interact with adenosine receptor-mediated signaling which regulates numerous neurological processes including sleep and waking behaviors. In mammals, caffeine is an adenosine receptor antagon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/1/63 |
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| author | Sonia Tremblay Yanqiqi Zeng Aixin Yue Kiana Chabot Abigail Mynahan Stephanie Desrochers Sarra Bridges S. Tariq Ahmad |
| author_facet | Sonia Tremblay Yanqiqi Zeng Aixin Yue Kiana Chabot Abigail Mynahan Stephanie Desrochers Sarra Bridges S. Tariq Ahmad |
| author_sort | Sonia Tremblay |
| collection | DOAJ |
| description | Caffeine and ethanol are among the most widely available and commonly consumed psychoactive substances. Both interact with adenosine receptor-mediated signaling which regulates numerous neurological processes including sleep and waking behaviors. In mammals, caffeine is an adenosine receptor antagonist and thus acts as a stimulant. Conversely, ethanol is a sedative because it promotes GABAergic neurotransmission, inhibits glutamatergic neurotransmission, and increases the amount of adenosine in the brain. Despite seemingly overlapping interactions, not much is known about the effect of caffeine on ethanol-induced sedation in <i>Drosophila</i>. In this study, using <i>Drosophila melanogaster</i> as a model, we show that caffeine supplementation in food delays the onset of ethanol-induced sedation in males and females of different strains. The resistance to sedation reverses upon caffeine withdrawal. Heterozygous adenosine receptor mutant flies are resistant to sedation. These findings suggest that caffeine and adenosine receptors modulate the sedative effects of ethanol in <i>Drosophila</i>. |
| first_indexed | 2024-03-09T13:32:20Z |
| format | Article |
| id | doaj.art-a103e581c9264821a68e35b35618e049 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T13:32:20Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a103e581c9264821a68e35b35618e0492023-11-30T21:16:50ZengMDPI AGBiology2079-77372022-12-011216310.3390/biology12010063Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i>Sonia Tremblay0Yanqiqi Zeng1Aixin Yue2Kiana Chabot3Abigail Mynahan4Stephanie Desrochers5Sarra Bridges6S. Tariq Ahmad7Department of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USADepartment of Biology, Colby College, Waterville, ME 04901, USACaffeine and ethanol are among the most widely available and commonly consumed psychoactive substances. Both interact with adenosine receptor-mediated signaling which regulates numerous neurological processes including sleep and waking behaviors. In mammals, caffeine is an adenosine receptor antagonist and thus acts as a stimulant. Conversely, ethanol is a sedative because it promotes GABAergic neurotransmission, inhibits glutamatergic neurotransmission, and increases the amount of adenosine in the brain. Despite seemingly overlapping interactions, not much is known about the effect of caffeine on ethanol-induced sedation in <i>Drosophila</i>. In this study, using <i>Drosophila melanogaster</i> as a model, we show that caffeine supplementation in food delays the onset of ethanol-induced sedation in males and females of different strains. The resistance to sedation reverses upon caffeine withdrawal. Heterozygous adenosine receptor mutant flies are resistant to sedation. These findings suggest that caffeine and adenosine receptors modulate the sedative effects of ethanol in <i>Drosophila</i>.https://www.mdpi.com/2079-7737/12/1/63caffeineadenosine receptorethanolsedation<i>Drosophila</i> |
| spellingShingle | Sonia Tremblay Yanqiqi Zeng Aixin Yue Kiana Chabot Abigail Mynahan Stephanie Desrochers Sarra Bridges S. Tariq Ahmad Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> Biology caffeine adenosine receptor ethanol sedation <i>Drosophila</i> |
| title | Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> |
| title_full | Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> |
| title_fullStr | Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> |
| title_full_unstemmed | Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> |
| title_short | Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> |
| title_sort | caffeine delays ethanol induced sedation in i drosophila i |
| topic | caffeine adenosine receptor ethanol sedation <i>Drosophila</i> |
| url | https://www.mdpi.com/2079-7737/12/1/63 |
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