Moyamoya disease during pregnancy and childbirth
Moyamoya disease (MMD) is a chronic vasculopathy characterized by progressive bilateral stenosis and occlusion of the terminal portion of the internal carotid artery (ICA) and the presence of an abnormal vascular network at the base of the brain, termed Moyamoya vessels (MMV). The main presentations...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2022-06-01
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| Series: | Romanian Journal of Neurology |
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| Online Access: | https://rjn.com.ro/articles/2022.2/RJN_2022_2_Art-06.pdf |
| _version_ | 1798036925459726336 |
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| author | Ioana-Elena Tarabasanu-Mihaila Francesca Gabriela Paslaru Alexandru Catalin Paslaru Nicolae Gica Gheorghe Peltecu Anca Maria Panaitescu |
| author_facet | Ioana-Elena Tarabasanu-Mihaila Francesca Gabriela Paslaru Alexandru Catalin Paslaru Nicolae Gica Gheorghe Peltecu Anca Maria Panaitescu |
| author_sort | Ioana-Elena Tarabasanu-Mihaila |
| collection | DOAJ |
| description | Moyamoya disease (MMD) is a chronic vasculopathy characterized by progressive bilateral stenosis and occlusion of the terminal portion of the internal carotid artery (ICA) and the presence of an abnormal vascular network at the base of the brain, termed Moyamoya vessels (MMV). The main presentations of MMD are ischemia and hemorrhage, and diagnosis is done via angiography. Cerebral events were reported in 5.1% of pregnancies of MMD diagnosed mothers, in Japan. In the case of MMD diagnosis due to cerebrovascular events during gestation, 34.7% of patients presented with an ischemic event, while 69.5% suffered from hemorrhage. During gestation, hemorrhagic events were found to occur mostly antepartum, after 24 weeks of gestation, while cerebral infarction peaked 3-7 days after delivery. No treatment has been found to halt or reverse the progress of the disease. Interventions focus on reducing the risk of stroke and cognitive disfunction as a result of ischemia. In the case of pregnant women suffering hemorrhage due to MMD, conservative treatment, as well as ventricle puncture and drainage were to be efficient, and did not severely impact the child. When diagnosed before pregnancy occurs, MMD under treatment does not pose a significantly increased risk of complications, compared to pregnancies in unaffected women. No evidence suggests that MMD is a contraindication for pregnancy. |
| first_indexed | 2024-04-11T21:19:39Z |
| format | Article |
| id | doaj.art-a103f347b4e6450b8c4c5637df30b8ed |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-11T21:19:39Z |
| publishDate | 2022-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-a103f347b4e6450b8c4c5637df30b8ed2022-12-22T04:02:42ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942022-06-0121212412710.37897/RJN.2022.2.6Moyamoya disease during pregnancy and childbirthIoana-Elena Tarabasanu-Mihaila0Francesca Gabriela Paslaru1Alexandru Catalin Paslaru2Nicolae Gica3Gheorghe Peltecu4Anca Maria Panaitescu5“Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaNeurosurgical Department, “Bagdasar-Arseni” Clinical Emergency Hospital, Bucharest, RomaniaDepartment of Physiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “Dr. Victor Gomoiu” Children’s Clinical Hospital, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaMoyamoya disease (MMD) is a chronic vasculopathy characterized by progressive bilateral stenosis and occlusion of the terminal portion of the internal carotid artery (ICA) and the presence of an abnormal vascular network at the base of the brain, termed Moyamoya vessels (MMV). The main presentations of MMD are ischemia and hemorrhage, and diagnosis is done via angiography. Cerebral events were reported in 5.1% of pregnancies of MMD diagnosed mothers, in Japan. In the case of MMD diagnosis due to cerebrovascular events during gestation, 34.7% of patients presented with an ischemic event, while 69.5% suffered from hemorrhage. During gestation, hemorrhagic events were found to occur mostly antepartum, after 24 weeks of gestation, while cerebral infarction peaked 3-7 days after delivery. No treatment has been found to halt or reverse the progress of the disease. Interventions focus on reducing the risk of stroke and cognitive disfunction as a result of ischemia. In the case of pregnant women suffering hemorrhage due to MMD, conservative treatment, as well as ventricle puncture and drainage were to be efficient, and did not severely impact the child. When diagnosed before pregnancy occurs, MMD under treatment does not pose a significantly increased risk of complications, compared to pregnancies in unaffected women. No evidence suggests that MMD is a contraindication for pregnancy.https://rjn.com.ro/articles/2022.2/RJN_2022_2_Art-06.pdfmoyamoya diseasepregnancybypass surgeryischemiahemorrhagic stroke |
| spellingShingle | Ioana-Elena Tarabasanu-Mihaila Francesca Gabriela Paslaru Alexandru Catalin Paslaru Nicolae Gica Gheorghe Peltecu Anca Maria Panaitescu Moyamoya disease during pregnancy and childbirth Romanian Journal of Neurology moyamoya disease pregnancy bypass surgery ischemia hemorrhagic stroke |
| title | Moyamoya disease during pregnancy and childbirth |
| title_full | Moyamoya disease during pregnancy and childbirth |
| title_fullStr | Moyamoya disease during pregnancy and childbirth |
| title_full_unstemmed | Moyamoya disease during pregnancy and childbirth |
| title_short | Moyamoya disease during pregnancy and childbirth |
| title_sort | moyamoya disease during pregnancy and childbirth |
| topic | moyamoya disease pregnancy bypass surgery ischemia hemorrhagic stroke |
| url | https://rjn.com.ro/articles/2022.2/RJN_2022_2_Art-06.pdf |
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