Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
Abstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Cur...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-83658-3 |
| _version_ | 1818420236667322368 |
|---|---|
| author | Matthew D. Laramie Benjamin L. Fouts William M. MacCuaig Emmanuel Buabeng Meredith A. Jones Priyabrata Mukherjee Bahareh Behkam Lacey R. McNally Maged Henary |
| author_facet | Matthew D. Laramie Benjamin L. Fouts William M. MacCuaig Emmanuel Buabeng Meredith A. Jones Priyabrata Mukherjee Bahareh Behkam Lacey R. McNally Maged Henary |
| author_sort | Matthew D. Laramie |
| collection | DOAJ |
| description | Abstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported. |
| first_indexed | 2024-12-14T12:51:16Z |
| format | Article |
| id | doaj.art-a1050fb86c204867a017ee7d6fe47964 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T12:51:16Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a1050fb86c204867a017ee7d6fe479642022-12-21T23:00:39ZengNature PortfolioScientific Reports2045-23222021-02-0111111210.1038/s41598-021-83658-3Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancerMatthew D. Laramie0Benjamin L. Fouts1William M. MacCuaig2Emmanuel Buabeng3Meredith A. Jones4Priyabrata Mukherjee5Bahareh Behkam6Lacey R. McNally7Maged Henary8Department of Chemistry, Georgia State UniversityDepartment of Surgery, Oklahoma Health Science CenterStephenson Cancer Center, Oklahoma Health Science CenterDepartment of Chemistry, Georgia State UniversityDepartment of Biomedical Engineering, University of OklahomaDepartment of Pathology, Oklahoma Health Science CenterDepartment of Mechanical Engineering, Virginia Tech UniversityDepartment of Surgery, Oklahoma Health Science CenterDepartment of Chemistry, Georgia State UniversityAbstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.https://doi.org/10.1038/s41598-021-83658-3 |
| spellingShingle | Matthew D. Laramie Benjamin L. Fouts William M. MacCuaig Emmanuel Buabeng Meredith A. Jones Priyabrata Mukherjee Bahareh Behkam Lacey R. McNally Maged Henary Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer Scientific Reports |
| title | Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer |
| title_full | Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer |
| title_fullStr | Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer |
| title_full_unstemmed | Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer |
| title_short | Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer |
| title_sort | improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer |
| url | https://doi.org/10.1038/s41598-021-83658-3 |
| work_keys_str_mv | AT matthewdlaramie improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT benjaminlfouts improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT williammmaccuaig improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT emmanuelbuabeng improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT meredithajones improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT priyabratamukherjee improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT baharehbehkam improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT laceyrmcnally improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer AT magedhenary improvedpentamethinecyaninenanosensorsforoptoacousticimagingofpancreaticcancer |