Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light
The progressive loss of the regenerative potential of tissues is one of the most obvious consequences of aging, driven by altered intercellular communication, cell senescence and niche-specific stem cell exhaustion, among other drivers. Mesenchymal tissues, such as bone, cartilage and fat, which ori...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/10/1043 |
| _version_ | 1797514120767995904 |
|---|---|
| author | Arantza Infante Clara I. Rodríguez |
| author_facet | Arantza Infante Clara I. Rodríguez |
| author_sort | Arantza Infante |
| collection | DOAJ |
| description | The progressive loss of the regenerative potential of tissues is one of the most obvious consequences of aging, driven by altered intercellular communication, cell senescence and niche-specific stem cell exhaustion, among other drivers. Mesenchymal tissues, such as bone, cartilage and fat, which originate from mesenchymal stem cell (MSC) differentiation, are especially affected by aging. Senescent MSCs show limited proliferative capacity and impairment in key defining features: their multipotent differentiation and secretory abilities, leading to diminished function and deleterious consequences for tissue homeostasis. In the past few years, several interventions to improve human healthspan by counteracting the cellular and molecular consequences of aging have moved closer to the clinic. Taking into account the MSC exhaustion occurring in aging, advanced therapies based on the potential use of young allogeneic MSCs and derivatives, such as extracellular vesicles (EVs), are gaining attention. Based on encouraging pre-clinical and clinical data, this review assesses the strong potential of MSC-based (cell and cell-free) therapies to counteract age-related consequences in both physiological and premature aging scenarios. We also discuss the mechanisms of action of these therapies and the possibility of enhancing their clinical potential by exposing MSCs to niche-relevant signals. |
| first_indexed | 2024-03-10T06:27:08Z |
| format | Article |
| id | doaj.art-a1054d0679f846659b0b1000554ee3a6 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T06:27:08Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-a1054d0679f846659b0b1000554ee3a62023-11-22T18:49:46ZengMDPI AGJournal of Personalized Medicine2075-44262021-10-011110104310.3390/jpm11101043Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to LightArantza Infante0Clara I. Rodríguez1Stem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, 48903 Barakaldo, SpainStem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, 48903 Barakaldo, SpainThe progressive loss of the regenerative potential of tissues is one of the most obvious consequences of aging, driven by altered intercellular communication, cell senescence and niche-specific stem cell exhaustion, among other drivers. Mesenchymal tissues, such as bone, cartilage and fat, which originate from mesenchymal stem cell (MSC) differentiation, are especially affected by aging. Senescent MSCs show limited proliferative capacity and impairment in key defining features: their multipotent differentiation and secretory abilities, leading to diminished function and deleterious consequences for tissue homeostasis. In the past few years, several interventions to improve human healthspan by counteracting the cellular and molecular consequences of aging have moved closer to the clinic. Taking into account the MSC exhaustion occurring in aging, advanced therapies based on the potential use of young allogeneic MSCs and derivatives, such as extracellular vesicles (EVs), are gaining attention. Based on encouraging pre-clinical and clinical data, this review assesses the strong potential of MSC-based (cell and cell-free) therapies to counteract age-related consequences in both physiological and premature aging scenarios. We also discuss the mechanisms of action of these therapies and the possibility of enhancing their clinical potential by exposing MSCs to niche-relevant signals.https://www.mdpi.com/2075-4426/11/10/1043MSCscell therapiescell-free therapiesextracellular vesiclesphysiological agingpremature aging |
| spellingShingle | Arantza Infante Clara I. Rodríguez Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light Journal of Personalized Medicine MSCs cell therapies cell-free therapies extracellular vesicles physiological aging premature aging |
| title | Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light |
| title_full | Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light |
| title_fullStr | Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light |
| title_full_unstemmed | Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light |
| title_short | Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light |
| title_sort | cell and cell free therapies to counteract human premature and physiological aging mscs come to light |
| topic | MSCs cell therapies cell-free therapies extracellular vesicles physiological aging premature aging |
| url | https://www.mdpi.com/2075-4426/11/10/1043 |
| work_keys_str_mv | AT arantzainfante cellandcellfreetherapiestocounteracthumanprematureandphysiologicalagingmscscometolight AT clarairodriguez cellandcellfreetherapiestocounteracthumanprematureandphysiologicalagingmscscometolight |