Chemoenzymatic One-Pot Process for the Synthesis of Tetrahydroisoquinolines

Chemoenzymatic One-Pot Process for the Synthesis of Tetrahydroisoquinolines

1,2,3,4-Tetrahydroisoquinolines form a valuable scaffold for a variety of bioactive secondary metabolites and commercial pharmaceuticals. Due to the harsh or complex conditions of the conventional chemical synthesis of this molecular motif, alternative mild reaction pathways are in demand. Here we p...

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Bibliographic Details
Main Authors: Andreas Sebastian Klein, Anna Christina Albrecht, Jörg Pietruszka
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Catalysts
Subjects:
laccase
TEMPO
chemoenzymatic cascade
pharmaceutical scaffold
heterogeneous catalysis
homogeneous catalysis
Online Access:https://www.mdpi.com/2073-4344/11/11/1389

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