Towards long double-stranded chains and robust DNA-based data storage using the random code system
DNA has become a popular choice for next-generation storage media due to its high storage density and stability. As the storage medium of life’s information, DNA has significant storage capacity and low-cost, low-power replication and transcription capabilities. However, utilizing long double-strand...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1179867/full |
| _version_ | 1797805775490383872 |
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| author | Xu Yang Xiaolong Shi Langwen Lai Congzhou Chen Huaisheng Xu Ming Deng |
| author_facet | Xu Yang Xiaolong Shi Langwen Lai Congzhou Chen Huaisheng Xu Ming Deng |
| author_sort | Xu Yang |
| collection | DOAJ |
| description | DNA has become a popular choice for next-generation storage media due to its high storage density and stability. As the storage medium of life’s information, DNA has significant storage capacity and low-cost, low-power replication and transcription capabilities. However, utilizing long double-stranded DNA for storage can introduce unstable factors that make it difficult to meet the constraints of biological systems. To address this challenge, we have designed a highly robust coding scheme called the “random code system,” inspired by the idea of fountain codes. The random code system includes the establishment of a random matrix, Gaussian preprocessing, and random equilibrium. Compared to Luby transform codes (LT codes), random code (RC) has better robustness and recovery ability of lost information. In biological experiments, we successfully stored 29,390 bits of data in 25,700 bp chains, achieving a storage density of 1.78 bits per nucleotide. These results demonstrate the potential for using long double-stranded DNA and the random code system for robust DNA-based data storage. |
| first_indexed | 2024-03-13T05:57:09Z |
| format | Article |
| id | doaj.art-a106d4bb3a7d4502a53b1795de742142 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-13T05:57:09Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a106d4bb3a7d4502a53b1795de7421422023-06-13T04:31:47ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-06-011410.3389/fgene.2023.11798671179867Towards long double-stranded chains and robust DNA-based data storage using the random code systemXu Yang0Xiaolong Shi1Langwen Lai2Congzhou Chen3Huaisheng Xu4Ming Deng5Institute of Computing Science and Technology, Guangzhou University, Guangzhou, ChinaInstitute of Computing Science and Technology, Guangzhou University, Guangzhou, ChinaInstitute of Computing Science and Technology, Guangzhou University, Guangzhou, ChinaCollege of Information Science and Technology, Beijing University of Chemical Technology, Beijing, ChinaInstitute of Computing Science and Technology, Guangzhou University, Guangzhou, ChinaInstitute of Computing Science and Technology, Guangzhou University, Guangzhou, ChinaDNA has become a popular choice for next-generation storage media due to its high storage density and stability. As the storage medium of life’s information, DNA has significant storage capacity and low-cost, low-power replication and transcription capabilities. However, utilizing long double-stranded DNA for storage can introduce unstable factors that make it difficult to meet the constraints of biological systems. To address this challenge, we have designed a highly robust coding scheme called the “random code system,” inspired by the idea of fountain codes. The random code system includes the establishment of a random matrix, Gaussian preprocessing, and random equilibrium. Compared to Luby transform codes (LT codes), random code (RC) has better robustness and recovery ability of lost information. In biological experiments, we successfully stored 29,390 bits of data in 25,700 bp chains, achieving a storage density of 1.78 bits per nucleotide. These results demonstrate the potential for using long double-stranded DNA and the random code system for robust DNA-based data storage.https://www.frontiersin.org/articles/10.3389/fgene.2023.1179867/fullDNA-based data storagelong double-stranded chainsrandom matrixrandom equilibriumhighly robustrandom code system |
| spellingShingle | Xu Yang Xiaolong Shi Langwen Lai Congzhou Chen Huaisheng Xu Ming Deng Towards long double-stranded chains and robust DNA-based data storage using the random code system Frontiers in Genetics DNA-based data storage long double-stranded chains random matrix random equilibrium highly robust random code system |
| title | Towards long double-stranded chains and robust DNA-based data storage using the random code system |
| title_full | Towards long double-stranded chains and robust DNA-based data storage using the random code system |
| title_fullStr | Towards long double-stranded chains and robust DNA-based data storage using the random code system |
| title_full_unstemmed | Towards long double-stranded chains and robust DNA-based data storage using the random code system |
| title_short | Towards long double-stranded chains and robust DNA-based data storage using the random code system |
| title_sort | towards long double stranded chains and robust dna based data storage using the random code system |
| topic | DNA-based data storage long double-stranded chains random matrix random equilibrium highly robust random code system |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1179867/full |
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