Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil
Rotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix®) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccina...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300012&lng=en&tlng=en |
| _version_ | 1797718376089387008 |
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| author | Sarah Cristina Fontes Vieira Ricardo Queiroz Gurgel Andrew Kirby Isis Pinheiro Barreto Liane Desiderio de Souza Oderlan Carvalho Oliveira Jailson de Barros Correia Winifred Dove Nigel A Cunliffe Luis E Cuevas |
| author_facet | Sarah Cristina Fontes Vieira Ricardo Queiroz Gurgel Andrew Kirby Isis Pinheiro Barreto Liane Desiderio de Souza Oderlan Carvalho Oliveira Jailson de Barros Correia Winifred Dove Nigel A Cunliffe Luis E Cuevas |
| author_sort | Sarah Cristina Fontes Vieira |
| collection | DOAJ |
| description | Rotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix®) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccinated). We followed two groups of 250 children under one year old, who were enrolled in December 2006 from a low-income residential area in Northeast Brazil. The children were monitored every two weeks for two years. Stool samples from children with diarrhoea were examined for the presence of rotavirus. Rotaviruses were genotyped using real time-polymerase chain reaction. The mean numbers of all-cause diarrhoea episodes/child (adjusted for age) in the first year were 0.87 and 0.84, in vaccinated and unvaccinated children, respectively. During the second year, the number of episodes/child decreased to 0.52 and 0.42. Only 16 (4.9%) of 330 stool samples were rotavirus-positive (10 vaccinated and 6 unvaccinated children) and only P[4]G2 rotaviruses were identified. All-cause diarrhoea episodes were more severe in unvaccinated children in the first year of age (p < 0.05), while vaccinated children had more severe episodes 18 months after vaccination. Rotavirus diarrhoea incidence was very low in both groups. |
| first_indexed | 2024-03-12T08:50:06Z |
| format | Article |
| id | doaj.art-a10821207a214f6f85c7b1d9b757c173 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:50:06Z |
| publishDate | 2011-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-a10821207a214f6f85c7b1d9b757c1732023-09-02T16:22:02ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-05-01106333033410.1590/S0074-02762011000300012S0074-02762011000300012Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast BrazilSarah Cristina Fontes Vieira0Ricardo Queiroz Gurgel1Andrew Kirby2Isis Pinheiro Barreto3Liane Desiderio de Souza4Oderlan Carvalho Oliveira5Jailson de Barros Correia6Winifred Dove7Nigel A Cunliffe8Luis E Cuevas9Universidade Federal de SergipeUniversidade Federal de SergipeInstitute of Infection and Global HealthUniversidade Federal de SergipeUniversidade Federal de SergipeUniversidade Federal de SergipeInstituto de Medicina Integral Professor Fernando FigueiraInstitute of Infection and Global HealthInstitute of Infection and Global HealthUniversity of LiverpoolRotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix®) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccinated). We followed two groups of 250 children under one year old, who were enrolled in December 2006 from a low-income residential area in Northeast Brazil. The children were monitored every two weeks for two years. Stool samples from children with diarrhoea were examined for the presence of rotavirus. Rotaviruses were genotyped using real time-polymerase chain reaction. The mean numbers of all-cause diarrhoea episodes/child (adjusted for age) in the first year were 0.87 and 0.84, in vaccinated and unvaccinated children, respectively. During the second year, the number of episodes/child decreased to 0.52 and 0.42. Only 16 (4.9%) of 330 stool samples were rotavirus-positive (10 vaccinated and 6 unvaccinated children) and only P[4]G2 rotaviruses were identified. All-cause diarrhoea episodes were more severe in unvaccinated children in the first year of age (p < 0.05), while vaccinated children had more severe episodes 18 months after vaccination. Rotavirus diarrhoea incidence was very low in both groups.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300012&lng=en&tlng=endiarrhoearotavirusvaccinecohortchildrenBrazil |
| spellingShingle | Sarah Cristina Fontes Vieira Ricardo Queiroz Gurgel Andrew Kirby Isis Pinheiro Barreto Liane Desiderio de Souza Oderlan Carvalho Oliveira Jailson de Barros Correia Winifred Dove Nigel A Cunliffe Luis E Cuevas Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil Memorias do Instituto Oswaldo Cruz diarrhoea rotavirus vaccine cohort children Brazil |
| title | Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil |
| title_full | Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil |
| title_fullStr | Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil |
| title_full_unstemmed | Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil |
| title_short | Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil |
| title_sort | acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in northeast brazil |
| topic | diarrhoea rotavirus vaccine cohort children Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300012&lng=en&tlng=en |
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