Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/9/5/832/ |
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| author | Yong-Jun Lu Zhi-Gang She Yong-Cheng Lin Miao Yu Cai-Huan Huang Xun Zhu Hong-Bo Huang Bin Chen Jia-Hui Pan |
| author_facet | Yong-Jun Lu Zhi-Gang She Yong-Cheng Lin Miao Yu Cai-Huan Huang Xun Zhu Hong-Bo Huang Bin Chen Jia-Hui Pan |
| author_sort | Yong-Jun Lu |
| collection | DOAJ |
| description | Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM. |
| first_indexed | 2024-04-11T12:43:21Z |
| format | Article |
| id | doaj.art-a109efd409ef4f66aaf49d1d31ea714c |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:43:21Z |
| publishDate | 2011-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a109efd409ef4f66aaf49d1d31ea714c2022-12-22T04:23:26ZengMDPI AGMarine Drugs1660-33972011-05-019583284310.3390/md9050832Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China SeaYong-Jun LuZhi-Gang SheYong-Cheng LinMiao YuCai-Huan HuangXun ZhuHong-Bo HuangBin ChenJia-Hui PanThree new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.http://www.mdpi.com/1660-3397/9/5/832/endophytic fungusAlternaria sp.bianthraquinonealterporriolcytotoxicity |
| spellingShingle | Yong-Jun Lu Zhi-Gang She Yong-Cheng Lin Miao Yu Cai-Huan Huang Xun Zhu Hong-Bo Huang Bin Chen Jia-Hui Pan Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea Marine Drugs endophytic fungus Alternaria sp. bianthraquinone alterporriol cytotoxicity |
| title | Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea |
| title_full | Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea |
| title_fullStr | Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea |
| title_full_unstemmed | Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea |
| title_short | Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea |
| title_sort | three bianthraquinone derivatives from the mangrove endophytic fungus alternaria sp zj9 6b from the south china sea |
| topic | endophytic fungus Alternaria sp. bianthraquinone alterporriol cytotoxicity |
| url | http://www.mdpi.com/1660-3397/9/5/832/ |
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