Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit
Patients with primary colorectal cancer can present with obstructions, tumor bleeding, or perforations, which represent acute complications. This paper aimed to analyze and compare the clinical and pathological profiles of two patient groups: one with colorectal cancer and a related complication and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/12/2016 |
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| author | Elena Savu Liviu Vasile Mircea-Sebastian Serbanescu Dragos Ovidiu Alexandru Ioana Andreea Gheonea Daniel Pirici Stefan Paitici Stelian Stefanita Mogoanta |
| author_facet | Elena Savu Liviu Vasile Mircea-Sebastian Serbanescu Dragos Ovidiu Alexandru Ioana Andreea Gheonea Daniel Pirici Stefan Paitici Stelian Stefanita Mogoanta |
| author_sort | Elena Savu |
| collection | DOAJ |
| description | Patients with primary colorectal cancer can present with obstructions, tumor bleeding, or perforations, which represent acute complications. This paper aimed to analyze and compare the clinical and pathological profiles of two patient groups: one with colorectal cancer and a related complication and another without any specific complication. We performed a five-year retrospective study on colorectal cancer patients admitted to a surgery unit and comparatively explored the main clinical and pathological features of the tumors belonging to the two groups. A total of 250 patients with colorectal cancer were included in the analysis. Of these, 117 (46.8%) had presented a type of complication. The comparative analysis that examined several clinical and pathological parameters showed a statistically significant difference for unfavorable prognosis factors in the group with complications. This was evident for features such as vascular and perineural invasion, lymph node involvement, pathological primary tumor stage, and TNM stage. Colorectal cancers with a related complication belonged to a group of tumors with a more aggressive histopathologic profile and more advanced stages. Furthermore, the comparable incidence of cases in the two groups of patients warrants further efforts to be made in terms of early detection and prognosis prediction of colorectal cancer. |
| first_indexed | 2024-03-11T02:34:57Z |
| format | Article |
| id | doaj.art-a10b6582243f436abc491fe1ed8c7617 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T02:34:57Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a10b6582243f436abc491fe1ed8c76172023-11-18T09:59:57ZengMDPI AGDiagnostics2075-44182023-06-011312201610.3390/diagnostics13122016Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery UnitElena Savu0Liviu Vasile1Mircea-Sebastian Serbanescu2Dragos Ovidiu Alexandru3Ioana Andreea Gheonea4Daniel Pirici5Stefan Paitici6Stelian Stefanita Mogoanta7Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Surgical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Medical Informatics, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Radiology and Medical Imaging, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaThird General Surgery Department, Clinical Emergency County Hospital, 200642 Craiova, RomaniaThird General Surgery Department, Clinical Emergency County Hospital, 200642 Craiova, RomaniaPatients with primary colorectal cancer can present with obstructions, tumor bleeding, or perforations, which represent acute complications. This paper aimed to analyze and compare the clinical and pathological profiles of two patient groups: one with colorectal cancer and a related complication and another without any specific complication. We performed a five-year retrospective study on colorectal cancer patients admitted to a surgery unit and comparatively explored the main clinical and pathological features of the tumors belonging to the two groups. A total of 250 patients with colorectal cancer were included in the analysis. Of these, 117 (46.8%) had presented a type of complication. The comparative analysis that examined several clinical and pathological parameters showed a statistically significant difference for unfavorable prognosis factors in the group with complications. This was evident for features such as vascular and perineural invasion, lymph node involvement, pathological primary tumor stage, and TNM stage. Colorectal cancers with a related complication belonged to a group of tumors with a more aggressive histopathologic profile and more advanced stages. Furthermore, the comparable incidence of cases in the two groups of patients warrants further efforts to be made in terms of early detection and prognosis prediction of colorectal cancer.https://www.mdpi.com/2075-4418/13/12/2016colorectal cancercolorectal cancer complicationsadenocarcinomahistopathologylymph nodesvascular invasion |
| spellingShingle | Elena Savu Liviu Vasile Mircea-Sebastian Serbanescu Dragos Ovidiu Alexandru Ioana Andreea Gheonea Daniel Pirici Stefan Paitici Stelian Stefanita Mogoanta Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit Diagnostics colorectal cancer colorectal cancer complications adenocarcinoma histopathology lymph nodes vascular invasion |
| title | Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit |
| title_full | Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit |
| title_fullStr | Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit |
| title_full_unstemmed | Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit |
| title_short | Clinicopathological Analysis of Complicated Colorectal Cancer: A Five-Year Retrospective Study from a Single Surgery Unit |
| title_sort | clinicopathological analysis of complicated colorectal cancer a five year retrospective study from a single surgery unit |
| topic | colorectal cancer colorectal cancer complications adenocarcinoma histopathology lymph nodes vascular invasion |
| url | https://www.mdpi.com/2075-4418/13/12/2016 |
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