In Vivo Intra‐Uterine Delivery of TAT‐Fused Cre Recombinase and CRISPR/Cas9 Editing System in Mice Unveil Histopathology of Pten/p53‐Deficient Endometrial Cancers

In Vivo Intra‐Uterine Delivery of TAT‐Fused Cre Recombinase and CRISPR/Cas9 Editing System in Mice Unveil Histopathology of Pten/p53‐Deficient Endometrial Cancers

Abstract Phosphatase and TENsin homolog (Pten) and p53 are two of the most frequently mutated tumor suppressor genes in endometrial cancer. However, the functional consequences and histopathological manifestation of concomitant p53 and Pten loss of function alterations in the development of endometr...

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Bibliographic Details
Main Authors: Raúl Navaridas, Maria Vidal‐Sabanés, Anna Ruiz‐Mitjana, Gisela Altés, Aida Perramon‐Güell, Andree Yeramian, Joaquim Egea, Mario Encinas, Sonia Gatius, Xavier Matias‐Guiu, Xavier Dolcet
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
cell penetrating peptides
Cre‐recombinase
CRISPR/Cas9
endometrial cancer
HIV1‐TAT
mouse model of cancer
Online Access:https://doi.org/10.1002/advs.202303134

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