Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment
This case report follows a 10-year-old castrated male Miniature Schnauzer dog presented with a history of incomplete surgical resection of an oral malignant melanoma (amelanotic type) on the right mandible. Melanoma vaccine therapy was administered due to incomplete surgical resection, however, new...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2023-12-01
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| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-202312-0004_canine-oral-melanoma-with-suspected-pulmonary-metastasis-combination-of-immunotherapy-and-tyrosine-kinase-inhi.php |
| _version_ | 1797371026148950016 |
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| author | KR Kim DH Kim MJ Jung DM Sihn SW Jeong JH Kim |
| author_facet | KR Kim DH Kim MJ Jung DM Sihn SW Jeong JH Kim |
| author_sort | KR Kim |
| collection | DOAJ |
| description | This case report follows a 10-year-old castrated male Miniature Schnauzer dog presented with a history of incomplete surgical resection of an oral malignant melanoma (amelanotic type) on the right mandible. Melanoma vaccine therapy was administered due to incomplete surgical resection, however, new masses were detected on the contralateral mandible and suspected pulmonary metastasis occurred at 2 weeks and 7 months, respectively, following the first melanoma vaccination. At the time of detecting the pulmonary metastasis, targeted chemotherapy was initiated with the owner's consent using imatinib (10 mg/kg/day, p.o.), a tyrosine kinase inhibitor (TKI). The patient did not show any significant adverse events related to both anticancer treatments. Three months following the first dose of imatinib, the absence of the suspected pulmonary metastatic nodules on radiography indicated complete remission. In conclusion, this report describes the achievement of clinical remission of suspected pulmonary metastatic oral malignant melanoma and an extension of survival time in a dog given a combination treatment of immunotherapy and tyrosine kinase inhibitor. |
| first_indexed | 2024-03-08T18:13:56Z |
| format | Article |
| id | doaj.art-a10f0a4f47b14430aa683b2c92e131be |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-03-08T18:13:56Z |
| publishDate | 2023-12-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-a10f0a4f47b14430aa683b2c92e131be2023-12-31T18:43:23ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922023-12-01681247748210.17221/90/2023-VETMEDvet-202312-0004Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatmentKR Kim0DH Kim1MJ Jung2DM Sihn3SW Jeong4JH Kim5KU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of KoreaKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of KoreaKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of KoreaKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of KoreaKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of KoreaKU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of KoreaThis case report follows a 10-year-old castrated male Miniature Schnauzer dog presented with a history of incomplete surgical resection of an oral malignant melanoma (amelanotic type) on the right mandible. Melanoma vaccine therapy was administered due to incomplete surgical resection, however, new masses were detected on the contralateral mandible and suspected pulmonary metastasis occurred at 2 weeks and 7 months, respectively, following the first melanoma vaccination. At the time of detecting the pulmonary metastasis, targeted chemotherapy was initiated with the owner's consent using imatinib (10 mg/kg/day, p.o.), a tyrosine kinase inhibitor (TKI). The patient did not show any significant adverse events related to both anticancer treatments. Three months following the first dose of imatinib, the absence of the suspected pulmonary metastatic nodules on radiography indicated complete remission. In conclusion, this report describes the achievement of clinical remission of suspected pulmonary metastatic oral malignant melanoma and an extension of survival time in a dog given a combination treatment of immunotherapy and tyrosine kinase inhibitor.https://vetmed.agriculturejournals.cz/artkey/vet-202312-0004_canine-oral-melanoma-with-suspected-pulmonary-metastasis-combination-of-immunotherapy-and-tyrosine-kinase-inhi.phpdogimatinibmalignant melanoma |
| spellingShingle | KR Kim DH Kim MJ Jung DM Sihn SW Jeong JH Kim Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment Veterinární Medicína dog imatinib malignant melanoma |
| title | Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment |
| title_full | Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment |
| title_fullStr | Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment |
| title_full_unstemmed | Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment |
| title_short | Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment |
| title_sort | canine oral melanoma with suspected pulmonary metastasis combination of immunotherapy and tyrosine kinase inhibitor treatment |
| topic | dog imatinib malignant melanoma |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-202312-0004_canine-oral-melanoma-with-suspected-pulmonary-metastasis-combination-of-immunotherapy-and-tyrosine-kinase-inhi.php |
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