Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments
In this research work, nanofibrous hybrids are manufactured, characterized, and assessed as active antiviral and antibacterial membranes. In more detail, both polyvinyl alcohol (PVA) and thermoplastic polyurethane (TPU) nanofibrous (NF) membranes and their composites with embedded silver nanoparticl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/11/1776 |
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| author | Latifah Abdullah Alshabanah Mohamed Hagar Laila A. Al-Mutabagani Ghada M. Abozaid Salwa M. Abdallah Nader Shehata Hoda Ahmed Ahmed H. Hassanin |
| author_facet | Latifah Abdullah Alshabanah Mohamed Hagar Laila A. Al-Mutabagani Ghada M. Abozaid Salwa M. Abdallah Nader Shehata Hoda Ahmed Ahmed H. Hassanin |
| author_sort | Latifah Abdullah Alshabanah |
| collection | DOAJ |
| description | In this research work, nanofibrous hybrids are manufactured, characterized, and assessed as active antiviral and antibacterial membranes. In more detail, both polyvinyl alcohol (PVA) and thermoplastic polyurethane (TPU) nanofibrous (NF) membranes and their composites with embedded silver nanoparticles (Ag NPs) are manufactured by an electrospinning process. Their morphological structures have been investigated by a scanning electron microscope (SEM) which revealed a homogenous distribution and almost beads-free fibers in all manufactured samples. Characterization with spectroscopic tools has been performed and proved the successful manufacturing of Ag-incorporated PVA and TPU hybrid nanofibers. The crystalline phase of the nanofibers has been determined using an X-ray diffractometer (XRD) whose patterns showed their crystalline nature at an angle value (2θ) of less than 20°. Subsequent screening of both antiviral and antibacterial potential activities of developed nanohybrid membranes has been explored against different viruses, including SARS-Cov-2 and some bacterial strains. As a novel approach, the current work highlights potential effects of several polymeric hybrids on antiviral and antibacterial activities particularly against SARS-Cov-2. Moreover, two types of polymers have been tested and compared; PVA of excellent biodegradable and hydrophilic properties, and TPU of excellent mechanical, super elasticity, hydrophobicity, and durability properties. Such extreme polymers can serve a wide range of applications such as PPE, filtration, wound healing, etc. Consequently, assessment of their antiviral/antibacterial activities, as host matrices for Ag NPs, is needed for different medical applications. Our results showed that TPU-Ag was more effective than PVA-Ag as HIV-1 antiviral nanohybrid as well as in deactivating spike proteins of SARS-Cov-2. Both TPU-Ag and PVA-Ag nanofibrous membranes were found to have superior antimicrobial performance by increasing Ag concentration from 2 to 4 wt.%. Additionally, the developed membranes showed acceptable physical and mechanical properties along with both antiviral and antibacterial activities, which can enable them to be used as a promising functional layer in Personal Protective Equipment (PPE) such as (surgical gowns, gloves, overshoes, hair caps, etc.). Therefore, the developed functional membranes can support the decrease of both coronavirus spread and bacterial contamination, particularly among healthcare professionals within their workplace settings. |
| first_indexed | 2024-03-10T10:56:47Z |
| format | Article |
| id | doaj.art-a11057efea1e46bcab36c6c4f069e6a3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T10:56:47Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-a11057efea1e46bcab36c6c4f069e6a32023-11-21T21:51:29ZengMDPI AGPolymers2073-43602021-05-011311177610.3390/polym13111776Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial AssessmentsLatifah Abdullah Alshabanah0Mohamed Hagar1Laila A. Al-Mutabagani2Ghada M. Abozaid3Salwa M. Abdallah4Nader Shehata5Hoda Ahmed6Ahmed H. Hassanin7Chemistry Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaChemistry Department, College of Sciences, Taibah University, Yanbu 30799, Saudi ArabiaChemistry Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaPharmaceutical Practice Department, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaMammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab (CAPL), Agricultural Research Center (ARC), Giza 12611, EgyptCenter of Smart Materials Nanotechnology and Photonics (CSMNP), Smart CI Research Center, Alexandria University, Alexandria 21544, EgyptChemistry Department, College of Sciences, Taibah University, Yanbu 30799, Saudi ArabiaCenter of Smart Materials Nanotechnology and Photonics (CSMNP), Smart CI Research Center, Alexandria University, Alexandria 21544, EgyptIn this research work, nanofibrous hybrids are manufactured, characterized, and assessed as active antiviral and antibacterial membranes. In more detail, both polyvinyl alcohol (PVA) and thermoplastic polyurethane (TPU) nanofibrous (NF) membranes and their composites with embedded silver nanoparticles (Ag NPs) are manufactured by an electrospinning process. Their morphological structures have been investigated by a scanning electron microscope (SEM) which revealed a homogenous distribution and almost beads-free fibers in all manufactured samples. Characterization with spectroscopic tools has been performed and proved the successful manufacturing of Ag-incorporated PVA and TPU hybrid nanofibers. The crystalline phase of the nanofibers has been determined using an X-ray diffractometer (XRD) whose patterns showed their crystalline nature at an angle value (2θ) of less than 20°. Subsequent screening of both antiviral and antibacterial potential activities of developed nanohybrid membranes has been explored against different viruses, including SARS-Cov-2 and some bacterial strains. As a novel approach, the current work highlights potential effects of several polymeric hybrids on antiviral and antibacterial activities particularly against SARS-Cov-2. Moreover, two types of polymers have been tested and compared; PVA of excellent biodegradable and hydrophilic properties, and TPU of excellent mechanical, super elasticity, hydrophobicity, and durability properties. Such extreme polymers can serve a wide range of applications such as PPE, filtration, wound healing, etc. Consequently, assessment of their antiviral/antibacterial activities, as host matrices for Ag NPs, is needed for different medical applications. Our results showed that TPU-Ag was more effective than PVA-Ag as HIV-1 antiviral nanohybrid as well as in deactivating spike proteins of SARS-Cov-2. Both TPU-Ag and PVA-Ag nanofibrous membranes were found to have superior antimicrobial performance by increasing Ag concentration from 2 to 4 wt.%. Additionally, the developed membranes showed acceptable physical and mechanical properties along with both antiviral and antibacterial activities, which can enable them to be used as a promising functional layer in Personal Protective Equipment (PPE) such as (surgical gowns, gloves, overshoes, hair caps, etc.). Therefore, the developed functional membranes can support the decrease of both coronavirus spread and bacterial contamination, particularly among healthcare professionals within their workplace settings.https://www.mdpi.com/2073-4360/13/11/1776nanofibers (PVA and TPU)Ag nanoparticlesantiviral-antibacterialCOVID-19 |
| spellingShingle | Latifah Abdullah Alshabanah Mohamed Hagar Laila A. Al-Mutabagani Ghada M. Abozaid Salwa M. Abdallah Nader Shehata Hoda Ahmed Ahmed H. Hassanin Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments Polymers nanofibers (PVA and TPU) Ag nanoparticles antiviral-antibacterial COVID-19 |
| title | Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments |
| title_full | Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments |
| title_fullStr | Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments |
| title_full_unstemmed | Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments |
| title_short | Hybrid Nanofibrous Membranes as a Promising Functional Layer for Personal Protection Equipment: Manufacturing and Antiviral/Antibacterial Assessments |
| title_sort | hybrid nanofibrous membranes as a promising functional layer for personal protection equipment manufacturing and antiviral antibacterial assessments |
| topic | nanofibers (PVA and TPU) Ag nanoparticles antiviral-antibacterial COVID-19 |
| url | https://www.mdpi.com/2073-4360/13/11/1776 |
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