Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2017.00145/full |
| _version_ | 1819229389346308096 |
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| author | Olena Bilyk Mackenzie Coatham Michael Jewer Michael Jewer Lynne-Marie Postovit |
| author_facet | Olena Bilyk Mackenzie Coatham Michael Jewer Michael Jewer Lynne-Marie Postovit |
| author_sort | Olena Bilyk |
| collection | DOAJ |
| description | Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis. We also summarize the current literature relating to EMT in the context of ovarian and endometrial carcinomas, with a particular focus on how molecular mechanisms and the tumor microenvironment can govern cancer cell plasticity, therapy resistance, and metastasis. |
| first_indexed | 2024-12-23T11:12:24Z |
| format | Article |
| id | doaj.art-a11157bced16481f94c244375253c6ea |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T11:12:24Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a11157bced16481f94c244375253c6ea2022-12-21T17:49:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2017-07-01710.3389/fonc.2017.00145269702Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease PathologyOlena Bilyk0Mackenzie Coatham1Michael Jewer2Michael Jewer3Lynne-Marie Postovit4Department of Oncology, University of Alberta, Edmonton, AB, CanadaDepartment of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, CanadaDepartment of Oncology, University of Alberta, Edmonton, AB, CanadaDepartment of Anatomy and Cell Biology, Western University, London, ON, CanadaDepartment of Oncology, University of Alberta, Edmonton, AB, CanadaEpithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis. We also summarize the current literature relating to EMT in the context of ovarian and endometrial carcinomas, with a particular focus on how molecular mechanisms and the tumor microenvironment can govern cancer cell plasticity, therapy resistance, and metastasis.http://journal.frontiersin.org/article/10.3389/fonc.2017.00145/fullepithelial-to-mesenchymal transitionadenomyosisendometriosisovarian cancerendometrial cancertumor microenvironment |
| spellingShingle | Olena Bilyk Mackenzie Coatham Michael Jewer Michael Jewer Lynne-Marie Postovit Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology Frontiers in Oncology epithelial-to-mesenchymal transition adenomyosis endometriosis ovarian cancer endometrial cancer tumor microenvironment |
| title | Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology |
| title_full | Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology |
| title_fullStr | Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology |
| title_full_unstemmed | Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology |
| title_short | Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology |
| title_sort | epithelial to mesenchymal transition in the female reproductive tract from normal functioning to disease pathology |
| topic | epithelial-to-mesenchymal transition adenomyosis endometriosis ovarian cancer endometrial cancer tumor microenvironment |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2017.00145/full |
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