A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide

A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide

Poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132), an organogermanium, is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (THGP) in aqueous solutions, and reduces inflammation, pain and cancer, whereas the underlying mechanisms remain unknown. Sulfides including H2S, a gasotransmitter, generat...

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Bibliographic Details
Main Authors: Fumiko Sekiguchi, Nene Koike, Yasuhiro Shimada, Kaho Sugimoto, Hiroshi Masuda, Takashi Nakamura, Hiroaki Yamaguchi, Genzoh Tanabe, Shinsuke Marumoto, Yoshihito Kasanami, Maho Tsubota, Tsuyako Ohkubo, Shigeru Yoshida, Atsufumi Kawabata
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
Organogermanium
Ge-132
Sulfide
Cav3.2 T-type calcium channel
Zinc
Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003512

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