Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia

Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia

Background: Despite the fundamental clinical significance of general anaesthesia, the cortical mechanism underlying anaesthetic-induced loss of consciousness (aLOC) remains elusive. Methods: Here, we measured the dynamics of two major cortical neurotransmitters, gamma-aminobutyric acid (GABA) and gl...

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Bibliographic Details
Main Authors: Juan Guo, Mingzi Ran, Zilong Gao, Xinxin Zhang, Dan Wang, Huiming Li, Shiyi Zhao, Wenzhi Sun, Hailong Dong, Ji Hu
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:EBioMedicine
Subjects:
GABA glutamate neurotransmission anaesthesia consciousness cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000657

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