Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida
Abstract This study aimed to analyze the phytochemical profile of essential oil obtained from the leaves of Coriandrum sativum L., and its antifungal activity against Candida spp. The research consisted of an in vitro study including collecting the vegetable product, analysis of its macronutrients,...
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Instituto Internacional de Ecologia
2023-01-01
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| Series: | Brazilian Journal of Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100424&tlng=en |
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| author | D. H. X. Barbosa C. R. Gondim M. Q. Silva-Henriques C. S. Soares D. N. Alves S. G. Santos R. D. Castro |
| author_facet | D. H. X. Barbosa C. R. Gondim M. Q. Silva-Henriques C. S. Soares D. N. Alves S. G. Santos R. D. Castro |
| author_sort | D. H. X. Barbosa |
| collection | DOAJ |
| description | Abstract This study aimed to analyze the phytochemical profile of essential oil obtained from the leaves of Coriandrum sativum L., and its antifungal activity against Candida spp. The research consisted of an in vitro study including collecting the vegetable product, analysis of its macronutrients, extraction, and chemical analysis of the essential oil, and assaying antifungal activity through minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), with growth inhibition kinetics, and the product’s effects on multi-species Candida biofilm. Nitrogen (47.08 g Kg-1), phosphorus (5.3 g Kg-1) and potassium (50.46 g Kg-1) levels were within the normal range. The major constituents were octanal, decanal, dec-(2E)-enal, and dodecanal. The MIC and MFC of the product evaluated against 11 tested Candida strains ranged from 31.25 to 250 μg/mL. There was inhibition of fungal growth during 24 hours of exposure at the 3 concentrations tested (250, 125, and 62.5 μg/mL). The concentration of 80 mg/mL promoted the greatest reduction in multispecies biofilm (70% reduction in biofilm). Coriandrum sativum L. essential oil extract is principally constituted of alcohols and aldehydes and presents fungicidal activity against Candida spp. in its in planktonic and biofilm forms. |
| first_indexed | 2024-04-10T22:29:53Z |
| format | Article |
| id | doaj.art-a113ab59355a473bbf45ff529d52cd4b |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-04-10T22:29:53Z |
| publishDate | 2023-01-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-a113ab59355a473bbf45ff529d52cd4b2023-01-17T07:33:37ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752023-01-018310.1590/1519-6984.264875Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm CandidaD. H. X. Barbosahttps://orcid.org/0000-0001-9267-9556C. R. Gondimhttps://orcid.org/0000-0001-8492-0362M. Q. Silva-Henriqueshttps://orcid.org/0000-0001-6682-529XC. S. Soareshttps://orcid.org/0000-0002-8730-698XD. N. Alveshttps://orcid.org/0000-0002-3072-0928S. G. Santoshttps://orcid.org/0000-0002-8458-8731R. D. Castrohttps://orcid.org/0000-0001-7986-7376Abstract This study aimed to analyze the phytochemical profile of essential oil obtained from the leaves of Coriandrum sativum L., and its antifungal activity against Candida spp. The research consisted of an in vitro study including collecting the vegetable product, analysis of its macronutrients, extraction, and chemical analysis of the essential oil, and assaying antifungal activity through minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), with growth inhibition kinetics, and the product’s effects on multi-species Candida biofilm. Nitrogen (47.08 g Kg-1), phosphorus (5.3 g Kg-1) and potassium (50.46 g Kg-1) levels were within the normal range. The major constituents were octanal, decanal, dec-(2E)-enal, and dodecanal. The MIC and MFC of the product evaluated against 11 tested Candida strains ranged from 31.25 to 250 μg/mL. There was inhibition of fungal growth during 24 hours of exposure at the 3 concentrations tested (250, 125, and 62.5 μg/mL). The concentration of 80 mg/mL promoted the greatest reduction in multispecies biofilm (70% reduction in biofilm). Coriandrum sativum L. essential oil extract is principally constituted of alcohols and aldehydes and presents fungicidal activity against Candida spp. in its in planktonic and biofilm forms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100424&tlng=enantifungalscandidiasisessential oilmedicinal plants |
| spellingShingle | D. H. X. Barbosa C. R. Gondim M. Q. Silva-Henriques C. S. Soares D. N. Alves S. G. Santos R. D. Castro Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida Brazilian Journal of Biology antifungals candidiasis essential oil medicinal plants |
| title | Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida |
| title_full | Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida |
| title_fullStr | Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida |
| title_full_unstemmed | Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida |
| title_short | Coriandrum sativum L. essential oil obtained from organic culture shows antifungal activity against planktonic and multi-biofilm Candida |
| title_sort | coriandrum sativum l essential oil obtained from organic culture shows antifungal activity against planktonic and multi biofilm candida |
| topic | antifungals candidiasis essential oil medicinal plants |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100424&tlng=en |
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