Isoform- and cell-state-specific APOE homeostasis and function
Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2456;epage=2466;aulast=Lindner |
| _version_ | 1797246050835103744 |
|---|---|
| author | Karina Lindner Anne-Claude Gavin |
| author_facet | Karina Lindner Anne-Claude Gavin |
| author_sort | Karina Lindner |
| collection | DOAJ |
| description | Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer’s disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer’s disease. |
| first_indexed | 2024-04-24T19:36:38Z |
| format | Article |
| id | doaj.art-a11975e73310483f9e9c304cffa30e05 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-24T19:36:38Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-a11975e73310483f9e9c304cffa30e052024-03-25T13:02:29ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-0119112456246610.4103/NRR.NRR-D-23-01470Isoform- and cell-state-specific APOE homeostasis and functionKarina LindnerAnne-Claude GavinApolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer’s disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer’s disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2456;epage=2466;aulast=Lindneralzheimer’s disease; apolipoprotein e; autophagy; cholesterol; lipid detoxification; lipid transport; lysosomal failure; metabolic impairment; triacylglycerol |
| spellingShingle | Karina Lindner Anne-Claude Gavin Isoform- and cell-state-specific APOE homeostasis and function Neural Regeneration Research alzheimer’s disease; apolipoprotein e; autophagy; cholesterol; lipid detoxification; lipid transport; lysosomal failure; metabolic impairment; triacylglycerol |
| title | Isoform- and cell-state-specific APOE homeostasis and function |
| title_full | Isoform- and cell-state-specific APOE homeostasis and function |
| title_fullStr | Isoform- and cell-state-specific APOE homeostasis and function |
| title_full_unstemmed | Isoform- and cell-state-specific APOE homeostasis and function |
| title_short | Isoform- and cell-state-specific APOE homeostasis and function |
| title_sort | isoform and cell state specific apoe homeostasis and function |
| topic | alzheimer’s disease; apolipoprotein e; autophagy; cholesterol; lipid detoxification; lipid transport; lysosomal failure; metabolic impairment; triacylglycerol |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2456;epage=2466;aulast=Lindner |
| work_keys_str_mv | AT karinalindner isoformandcellstatespecificapoehomeostasisandfunction AT anneclaudegavin isoformandcellstatespecificapoehomeostasisandfunction |