Isoform- and cell-state-specific APOE homeostasis and function

Isoform- and cell-state-specific APOE homeostasis and function

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental...

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Bibliographic Details
Main Authors: Karina Lindner, Anne-Claude Gavin
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
alzheimer’s disease; apolipoprotein e; autophagy; cholesterol; lipid detoxification; lipid transport; lysosomal failure; metabolic impairment; triacylglycerol
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2456;epage=2466;aulast=Lindner

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