The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial
Nefopam is a centrally acting non-opioid analgesic, and its efficacy in multimodal analgesia has been reported. This study aimed to assess the analgesic efficacy of intraoperative nefopam on postoperative pain after video-assisted thoracoscopic surgery (VATS) for lung cancer. Participants were rando...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/16/4849 |
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| author | Hyean Yeo Ji Won Choi Seungwon Lee Woo Seog Sim Soo Jung Park Heejoon Jeong Mikyung Yang Hyun Joo Ahn Jie Ae Kim Eun Ji Lee |
| author_facet | Hyean Yeo Ji Won Choi Seungwon Lee Woo Seog Sim Soo Jung Park Heejoon Jeong Mikyung Yang Hyun Joo Ahn Jie Ae Kim Eun Ji Lee |
| author_sort | Hyean Yeo |
| collection | DOAJ |
| description | Nefopam is a centrally acting non-opioid analgesic, and its efficacy in multimodal analgesia has been reported. This study aimed to assess the analgesic efficacy of intraoperative nefopam on postoperative pain after video-assisted thoracoscopic surgery (VATS) for lung cancer. Participants were randomly assigned to either the nefopam or the control group. The nefopam group received 20 mg of nefopam after induction and 15 min before the end of surgery. The control group received saline. The primary outcome was cumulative opioid consumption during the 6 h postoperatively. Pain intensities, the time to first request for rescue analgesia, adverse events during the 72 h postoperatively, and the incidence of chronic pain 3 months after surgery were evaluated. Ninety-nine patients were included in the analysis. Total opioid consumption during the 6 h postoperatively was comparable between the groups (nefopam group [<i>n</i> = 50] vs. control group [<i>n</i> = 49], 19.8 [13.5–25.3] mg vs. 20.3 [13.9–27.0] mg; median difference: −1.55, 95% CI: −6.64 to 3.69; <i>p</i> = 0.356). Pain intensity during the 72 h postoperatively and the incidence of chronic pain 3 months after surgery did not differ between the groups. Intraoperative nefopam did not decrease acute postoperative opioid consumption or pain intensity, nor did it reduce the incidence of chronic pain after VATS. |
| first_indexed | 2024-03-09T13:11:50Z |
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| id | doaj.art-a119b9624b754ceb90e3e35c4a22f40a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T13:11:50Z |
| publishDate | 2022-08-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a119b9624b754ceb90e3e35c4a22f40a2023-11-30T21:41:38ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011116484910.3390/jcm11164849The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled TrialHyean Yeo0Ji Won Choi1Seungwon Lee2Woo Seog Sim3Soo Jung Park4Heejoon Jeong5Mikyung Yang6Hyun Joo Ahn7Jie Ae Kim8Eun Ji Lee9Department of Anesthesiology and Pain Medicine, CHA Ilsan Medical Center, CHA University, Goyang 10414, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Anesthesiology and Pain Medicine, Seongnam Citizens Medical Center, Seongnam 13290, KoreaNefopam is a centrally acting non-opioid analgesic, and its efficacy in multimodal analgesia has been reported. This study aimed to assess the analgesic efficacy of intraoperative nefopam on postoperative pain after video-assisted thoracoscopic surgery (VATS) for lung cancer. Participants were randomly assigned to either the nefopam or the control group. The nefopam group received 20 mg of nefopam after induction and 15 min before the end of surgery. The control group received saline. The primary outcome was cumulative opioid consumption during the 6 h postoperatively. Pain intensities, the time to first request for rescue analgesia, adverse events during the 72 h postoperatively, and the incidence of chronic pain 3 months after surgery were evaluated. Ninety-nine patients were included in the analysis. Total opioid consumption during the 6 h postoperatively was comparable between the groups (nefopam group [<i>n</i> = 50] vs. control group [<i>n</i> = 49], 19.8 [13.5–25.3] mg vs. 20.3 [13.9–27.0] mg; median difference: −1.55, 95% CI: −6.64 to 3.69; <i>p</i> = 0.356). Pain intensity during the 72 h postoperatively and the incidence of chronic pain 3 months after surgery did not differ between the groups. Intraoperative nefopam did not decrease acute postoperative opioid consumption or pain intensity, nor did it reduce the incidence of chronic pain after VATS.https://www.mdpi.com/2077-0383/11/16/4849nefopamvideo-assisted thoracoscopic surgeryacute postoperative painopioid consumptionchronic post-surgical painlung cancer |
| spellingShingle | Hyean Yeo Ji Won Choi Seungwon Lee Woo Seog Sim Soo Jung Park Heejoon Jeong Mikyung Yang Hyun Joo Ahn Jie Ae Kim Eun Ji Lee The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial Journal of Clinical Medicine nefopam video-assisted thoracoscopic surgery acute postoperative pain opioid consumption chronic post-surgical pain lung cancer |
| title | The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial |
| title_full | The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial |
| title_fullStr | The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial |
| title_full_unstemmed | The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial |
| title_short | The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial |
| title_sort | lack of analgesic efficacy of nefopam after video assisted thoracoscopic surgery for lung cancer a randomized single blinded controlled trial |
| topic | nefopam video-assisted thoracoscopic surgery acute postoperative pain opioid consumption chronic post-surgical pain lung cancer |
| url | https://www.mdpi.com/2077-0383/11/16/4849 |
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