Small-scale dosimetry for alpha particle 241Am source cell irradiation and estimation of γ-H2AX foci distribution in prostate cancer cell line PC3

Small-scale dosimetry for alpha particle 241Am source cell irradiation and estimation of γ-H2AX foci distribution in prostate cancer cell line PC3

Abstract Background The development of new targeted alpha therapies motivates improving alpha particle dosimetry. For alpha particles, microscopic targets must be considered to estimate dosimetric quantities that can predict the biological response. As double-strand breaks (DSB) on DNA are the main...

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Bibliographic Details
Main Authors: Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand, Sven-Erik Strand
Format: Article
Language:English
Published: SpringerOpen 2022-07-01
Series:EJNMMI Physics
Subjects:
Small-scale dosimetry
Alpha particles
Monte Carlo simulation
γ-H2AX
PC3
Online Access:https://doi.org/10.1186/s40658-022-00475-x

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