Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products
Good health, of vital importance in order to carry out our daily routine, consists of both physical and mental health. Tyrosine (Tyr) deficiency as well as its excess are issues that can affect mental health and can generate disorders such as depression, anxiety, or stress. Tyr is the amino acid (AA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7528 |
| _version_ | 1797526943282757632 |
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| author | Ancuța Dinu Constantin Apetrei |
| author_facet | Ancuța Dinu Constantin Apetrei |
| author_sort | Ancuța Dinu |
| collection | DOAJ |
| description | Good health, of vital importance in order to carry out our daily routine, consists of both physical and mental health. Tyrosine (Tyr) deficiency as well as its excess are issues that can affect mental health and can generate disorders such as depression, anxiety, or stress. Tyr is the amino acid (AA) responsible for maintaining good mental health, and for this reason, the present research presents the development of new electrochemical sensors modified with polypyrrole (PPy) doped with different doping agents such as potassium hexacyanoferrate (II) (FeCN), sodium nitroprusside (NP), and sodium dodecyl sulfate (SDS) for a selective and sensitive detection of Tyr. The development of the sensors was carried out by chronoamperometry (CA) and the electrochemical characterization was carried out by cyclic voltammetry (CV). The detection limits (LOD) obtained with each modified sensor were 8.2 × 10<sup>−8</sup> M in the case of PPy /FeCN-SPCE, 4.3 × 10<sup>−7</sup> M in the case of PPy/NP-SPCE, and of 3.51 × 10<sup>−7</sup> M in the case of PPy/SDS-SPCE, thus demonstrating a good sensitivity of these sensors detecting L-Tyr. The validation of sensors was carried out through quantification of L-Tyr from three pharmaceutical products by the standard addition method with recoveries in the range 99.92–103.97%. Thus, the sensors present adequate selectivity and can be used in the pharmaceutical and medical fields. |
| first_indexed | 2024-03-10T09:37:29Z |
| format | Article |
| id | doaj.art-a11a598464864ab085535744089e82d4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:37:29Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a11a598464864ab085535744089e82d42023-11-22T03:59:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214752810.3390/ijms22147528Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical ProductsAncuța Dinu0Constantin Apetrei1Faculty of Science and Environment, “Dunărea de Jos” University of Galati, 800008 Galati, RomaniaFaculty of Science and Environment, “Dunărea de Jos” University of Galati, 800008 Galati, RomaniaGood health, of vital importance in order to carry out our daily routine, consists of both physical and mental health. Tyrosine (Tyr) deficiency as well as its excess are issues that can affect mental health and can generate disorders such as depression, anxiety, or stress. Tyr is the amino acid (AA) responsible for maintaining good mental health, and for this reason, the present research presents the development of new electrochemical sensors modified with polypyrrole (PPy) doped with different doping agents such as potassium hexacyanoferrate (II) (FeCN), sodium nitroprusside (NP), and sodium dodecyl sulfate (SDS) for a selective and sensitive detection of Tyr. The development of the sensors was carried out by chronoamperometry (CA) and the electrochemical characterization was carried out by cyclic voltammetry (CV). The detection limits (LOD) obtained with each modified sensor were 8.2 × 10<sup>−8</sup> M in the case of PPy /FeCN-SPCE, 4.3 × 10<sup>−7</sup> M in the case of PPy/NP-SPCE, and of 3.51 × 10<sup>−7</sup> M in the case of PPy/SDS-SPCE, thus demonstrating a good sensitivity of these sensors detecting L-Tyr. The validation of sensors was carried out through quantification of L-Tyr from three pharmaceutical products by the standard addition method with recoveries in the range 99.92–103.97%. Thus, the sensors present adequate selectivity and can be used in the pharmaceutical and medical fields.https://www.mdpi.com/1422-0067/22/14/7528L-Tyrosinepolypyrrolesensoramino acidcyclic voltammetrychronoamperometry |
| spellingShingle | Ancuța Dinu Constantin Apetrei Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products International Journal of Molecular Sciences L-Tyrosine polypyrrole sensor amino acid cyclic voltammetry chronoamperometry |
| title | Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products |
| title_full | Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products |
| title_fullStr | Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products |
| title_full_unstemmed | Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products |
| title_short | Development of Polypyrrole Modified Screen-Printed Carbon Electrode Based Sensors for Determination of L-Tyrosine in Pharmaceutical Products |
| title_sort | development of polypyrrole modified screen printed carbon electrode based sensors for determination of l tyrosine in pharmaceutical products |
| topic | L-Tyrosine polypyrrole sensor amino acid cyclic voltammetry chronoamperometry |
| url | https://www.mdpi.com/1422-0067/22/14/7528 |
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