Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks
Microplastics (MPs) are ubiquitous in environmental media and human diets and can enrich organic contaminants, including polycyclic aromatic hydrocarbons (PAHs) and their derivatives. The bioaccessibilities and triggering cancer risks of MP-sorbed PAHs and PAH derivatives are closely linked with hum...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022003865 |
| _version_ | 1811274650768900096 |
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| author | Xiaojie Hu Qing Yu Michael Gatheru Waigi Wanting Ling Chao Qin Jian Wang Yanzheng Gao |
| author_facet | Xiaojie Hu Qing Yu Michael Gatheru Waigi Wanting Ling Chao Qin Jian Wang Yanzheng Gao |
| author_sort | Xiaojie Hu |
| collection | DOAJ |
| description | Microplastics (MPs) are ubiquitous in environmental media and human diets and can enrich organic contaminants, including polycyclic aromatic hydrocarbons (PAHs) and their derivatives. The bioaccessibilities and triggering cancer risks of MP-sorbed PAHs and PAH derivatives are closely linked with human health, which, however, were rarely focused on. This study explored the sorption behaviors of phenanthrene (PHE) and PHE derivatives on polyethylene (PE), polypropylene (PP), and polystyrene (PS) MPs, and assessed their bioaccessibilities in gastrointestinal fluids as well as their inducing human cancer risks. PE MPs harbored the highest sorption capacity, secondly the PP MPs, then the PS ones. Sorption of PHE and PHE derivatives on MPs was positively correlated with their hydrophobicities. The bioaccessibilities of sorbed PHE and PHE derivatives could reach 53.59 %±0.46 %-90.28 %±0.92 % in gastrointestinal fluids and 81.34 %±0.77 %-98.72 %±1.44 % in gastrointestinal fluids with the addition of Tenax (more close to the bioavailability). The hydrophobicities also controlled the bioaccessibilities of PHE and PHE derivatives in gastric fluids, and those in intestinal fluids with Tenax for PS MPs. The incremental lifetime cancer risk (ILCR) values for PHE, PHE-Cl, and PHE-NO2 on MPs at tested concentrations were all higher than the USEPA-suggested safety limit (10−6), and most of them were even higher than 10-4, which thus indicates serious cancer risks. This study promoted our understanding of the potential health threats posed by organic pollutant-bearing MPs in the environment. |
| first_indexed | 2024-04-12T23:22:53Z |
| format | Article |
| id | doaj.art-a11e758b204a45b0bf73b186b6a2543d |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-12T23:22:53Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-a11e758b204a45b0bf73b186b6a2543d2022-12-22T03:12:29ZengElsevierEnvironment International0160-41202022-10-01168107459Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risksXiaojie Hu0Qing Yu1Michael Gatheru Waigi2Wanting Ling3Chao Qin4Jian Wang5Yanzheng Gao6Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaInstitute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaInstitute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaInstitute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaInstitute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaCorresponding authors at: Weigang Road 1, Nanjing 210095, China.; Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaCorresponding authors at: Weigang Road 1, Nanjing 210095, China.; Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR ChinaMicroplastics (MPs) are ubiquitous in environmental media and human diets and can enrich organic contaminants, including polycyclic aromatic hydrocarbons (PAHs) and their derivatives. The bioaccessibilities and triggering cancer risks of MP-sorbed PAHs and PAH derivatives are closely linked with human health, which, however, were rarely focused on. This study explored the sorption behaviors of phenanthrene (PHE) and PHE derivatives on polyethylene (PE), polypropylene (PP), and polystyrene (PS) MPs, and assessed their bioaccessibilities in gastrointestinal fluids as well as their inducing human cancer risks. PE MPs harbored the highest sorption capacity, secondly the PP MPs, then the PS ones. Sorption of PHE and PHE derivatives on MPs was positively correlated with their hydrophobicities. The bioaccessibilities of sorbed PHE and PHE derivatives could reach 53.59 %±0.46 %-90.28 %±0.92 % in gastrointestinal fluids and 81.34 %±0.77 %-98.72 %±1.44 % in gastrointestinal fluids with the addition of Tenax (more close to the bioavailability). The hydrophobicities also controlled the bioaccessibilities of PHE and PHE derivatives in gastric fluids, and those in intestinal fluids with Tenax for PS MPs. The incremental lifetime cancer risk (ILCR) values for PHE, PHE-Cl, and PHE-NO2 on MPs at tested concentrations were all higher than the USEPA-suggested safety limit (10−6), and most of them were even higher than 10-4, which thus indicates serious cancer risks. This study promoted our understanding of the potential health threats posed by organic pollutant-bearing MPs in the environment.http://www.sciencedirect.com/science/article/pii/S0160412022003865MicroplasticsPAH-derivativesSorption behaviorBioaccessibilityHuman cancer risks |
| spellingShingle | Xiaojie Hu Qing Yu Michael Gatheru Waigi Wanting Ling Chao Qin Jian Wang Yanzheng Gao Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks Environment International Microplastics PAH-derivatives Sorption behavior Bioaccessibility Human cancer risks |
| title | Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks |
| title_full | Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks |
| title_fullStr | Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks |
| title_full_unstemmed | Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks |
| title_short | Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks |
| title_sort | microplastics sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks |
| topic | Microplastics PAH-derivatives Sorption behavior Bioaccessibility Human cancer risks |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022003865 |
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