Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study
Abstract Background Insulin resistance (IR) is a major pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity to assess IR and NAFLD due to its simplicity and low cost. The aim of the current study was to evaluate the relationshi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01811-5 |
| _version_ | 1797849918158667776 |
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| author | Sethapong Lertsakulbunlue Mathirut Mungthin Ram Rangsin Anupong Kantiwong Boonsub Sakboonyarat |
| author_facet | Sethapong Lertsakulbunlue Mathirut Mungthin Ram Rangsin Anupong Kantiwong Boonsub Sakboonyarat |
| author_sort | Sethapong Lertsakulbunlue |
| collection | DOAJ |
| description | Abstract Background Insulin resistance (IR) is a major pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity to assess IR and NAFLD due to its simplicity and low cost. The aim of the current study was to evaluate the relationship between the TyG index and aminotransferase. Methods A serial cross-sectional study was conducted among 232,235 Royal Thai Army (RTA) personnel aged 35–60 years from 2017–2021. Elevated aminotransferase was defined as ≥ 40 U/L and ≥ 35 U/L among males and females, respectively. A linear regression analysis between the TyG index and log-transformed aminotransferase was performed. High- and low-TyG index groups were divided according to Youden’s index cut point for predicting elevated aminotransferase. Multivariable logistic analysis was also utilized to investigate the association between the TyG index and elevated aminotransferase. Results The TyG index revealed a dose‒response relationship with log-transformed aminotransferase in both sexes and all age groups. The TyG index was positively associated with the prevalence of elevated aminotransferases. In comparison with the first TyG quartile (< 8.37), participants in the fourth quartile (> 9.23) had a higher chance for elevated ALT (AOR: 2.81, 95% CI: 2.71–2.90 for males and AOR: 4.01, 95% CI: 3.50–4.60 for females, P < 0.001 for both). In the fourth TyG quartile, the prevalence of elevated ALT was 47.8% and 40.2% in the participants aged 35–44 and male participants, respectively. Conclusion A high TyG index is a novel risk factor for elevated aminotransferase among RTA personnel. Those with a high TyG index should be screened for elevated aminotransferase, particularly males aged 35–44 years. |
| first_indexed | 2024-04-09T18:51:55Z |
| format | Article |
| id | doaj.art-a11fa35c28a8424db75c7cbd3433d3ba |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-09T18:51:55Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a11fa35c28a8424db75c7cbd3433d3ba2023-04-09T11:25:45ZengBMCLipids in Health and Disease1476-511X2023-04-0122111310.1186/s12944-023-01811-5Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional studySethapong Lertsakulbunlue0Mathirut Mungthin1Ram Rangsin2Anupong Kantiwong3Boonsub Sakboonyarat4Department of Pharmacology, Phramongkutklao College of MedicineDepartment of Parasitology, Phramongkutklao College of MedicineDepartment of Military and Community Medicine, Phramongkutklao College of MedicineDepartment of Pharmacology, Phramongkutklao College of MedicineDepartment of Military and Community Medicine, Phramongkutklao College of MedicineAbstract Background Insulin resistance (IR) is a major pathogenesis of nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index has recently gained popularity to assess IR and NAFLD due to its simplicity and low cost. The aim of the current study was to evaluate the relationship between the TyG index and aminotransferase. Methods A serial cross-sectional study was conducted among 232,235 Royal Thai Army (RTA) personnel aged 35–60 years from 2017–2021. Elevated aminotransferase was defined as ≥ 40 U/L and ≥ 35 U/L among males and females, respectively. A linear regression analysis between the TyG index and log-transformed aminotransferase was performed. High- and low-TyG index groups were divided according to Youden’s index cut point for predicting elevated aminotransferase. Multivariable logistic analysis was also utilized to investigate the association between the TyG index and elevated aminotransferase. Results The TyG index revealed a dose‒response relationship with log-transformed aminotransferase in both sexes and all age groups. The TyG index was positively associated with the prevalence of elevated aminotransferases. In comparison with the first TyG quartile (< 8.37), participants in the fourth quartile (> 9.23) had a higher chance for elevated ALT (AOR: 2.81, 95% CI: 2.71–2.90 for males and AOR: 4.01, 95% CI: 3.50–4.60 for females, P < 0.001 for both). In the fourth TyG quartile, the prevalence of elevated ALT was 47.8% and 40.2% in the participants aged 35–44 and male participants, respectively. Conclusion A high TyG index is a novel risk factor for elevated aminotransferase among RTA personnel. Those with a high TyG index should be screened for elevated aminotransferase, particularly males aged 35–44 years.https://doi.org/10.1186/s12944-023-01811-5Triglyceride glucose indexPrevalenceAssociationRelationshipAminotransferaseNAFLD |
| spellingShingle | Sethapong Lertsakulbunlue Mathirut Mungthin Ram Rangsin Anupong Kantiwong Boonsub Sakboonyarat Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study Lipids in Health and Disease Triglyceride glucose index Prevalence Association Relationship Aminotransferase NAFLD |
| title | Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study |
| title_full | Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study |
| title_fullStr | Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study |
| title_full_unstemmed | Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study |
| title_short | Relationship between triglyceride-glucose index and aminotransferase among Royal Thai Army personnel 2017–2021: a serial cross-sectional study |
| title_sort | relationship between triglyceride glucose index and aminotransferase among royal thai army personnel 2017 2021 a serial cross sectional study |
| topic | Triglyceride glucose index Prevalence Association Relationship Aminotransferase NAFLD |
| url | https://doi.org/10.1186/s12944-023-01811-5 |
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