Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers
Riboflavin, a water-soluble vitamin B2, possesses unique biological and physicochemical properties. Its photosensitizing properties make it suitable for various biological applications, such as pathogen inactivation and photodynamic therapy. However, the effectiveness of riboflavin as a photosensiti...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/18/2304 |
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| author | Małgorzata Insińska-Rak Marek Sikorski Agnieszka Wolnicka-Glubisz |
| author_facet | Małgorzata Insińska-Rak Marek Sikorski Agnieszka Wolnicka-Glubisz |
| author_sort | Małgorzata Insińska-Rak |
| collection | DOAJ |
| description | Riboflavin, a water-soluble vitamin B2, possesses unique biological and physicochemical properties. Its photosensitizing properties make it suitable for various biological applications, such as pathogen inactivation and photodynamic therapy. However, the effectiveness of riboflavin as a photosensitizer is hindered by its degradation upon exposure to light. The review aims to highlight the significance of riboflavin and its derivatives as potential photosensitizers for use in photodynamic therapy. Additionally, a concise overview of photodynamic therapy and utilization of blue light in dermatology is provided, as well as the photochemistry and photobiophysics of riboflavin and its derivatives. Particular emphasis is given to the latest findings on the use of acetylated 3-methyltetraacetyl-riboflavin derivative (3MeTARF) in photodynamic therapy. |
| first_indexed | 2024-03-10T22:56:29Z |
| format | Article |
| id | doaj.art-a120109c7b7d49a884856103d88360a4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:56:29Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a120109c7b7d49a884856103d88360a42023-11-19T10:00:09ZengMDPI AGCells2073-44092023-09-011218230410.3390/cells12182304Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin CancersMałgorzata Insińska-Rak0Marek Sikorski1Agnieszka Wolnicka-Glubisz2Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, PolandDepartment of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, PolandRiboflavin, a water-soluble vitamin B2, possesses unique biological and physicochemical properties. Its photosensitizing properties make it suitable for various biological applications, such as pathogen inactivation and photodynamic therapy. However, the effectiveness of riboflavin as a photosensitizer is hindered by its degradation upon exposure to light. The review aims to highlight the significance of riboflavin and its derivatives as potential photosensitizers for use in photodynamic therapy. Additionally, a concise overview of photodynamic therapy and utilization of blue light in dermatology is provided, as well as the photochemistry and photobiophysics of riboflavin and its derivatives. Particular emphasis is given to the latest findings on the use of acetylated 3-methyltetraacetyl-riboflavin derivative (3MeTARF) in photodynamic therapy.https://www.mdpi.com/2073-4409/12/18/2304skin cancer3MeTARFmelanomariboflavinlumichromesinglet oxygen |
| spellingShingle | Małgorzata Insińska-Rak Marek Sikorski Agnieszka Wolnicka-Glubisz Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers Cells skin cancer 3MeTARF melanoma riboflavin lumichrome singlet oxygen |
| title | Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers |
| title_full | Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers |
| title_fullStr | Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers |
| title_full_unstemmed | Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers |
| title_short | Riboflavin and Its Derivates as Potential Photosensitizers in the Photodynamic Treatment of Skin Cancers |
| title_sort | riboflavin and its derivates as potential photosensitizers in the photodynamic treatment of skin cancers |
| topic | skin cancer 3MeTARF melanoma riboflavin lumichrome singlet oxygen |
| url | https://www.mdpi.com/2073-4409/12/18/2304 |
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