Recurrent Adamantinoma With Fibrous Dysplasia-like Feature
Adamantinoma (AD) is a rare, slow-growing primary malignant bone tumor characterized by a biphasic morphology of clusters of epithelial cells and spindle cell osteofibrous components. A strong relationship between AD and osteofibrous dysplasia (OFD) has been proposed, while fibrous dysplasia (FD) ha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-04-01
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| Series: | Clinical Pathology |
| Online Access: | https://doi.org/10.1177/2632010X241240391 |
| _version_ | 1797217457059921920 |
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| author | Anja Petaros Veljko Šantić Anita Savić Vuković Petar Perić Nives Jonjić |
| author_facet | Anja Petaros Veljko Šantić Anita Savić Vuković Petar Perić Nives Jonjić |
| author_sort | Anja Petaros |
| collection | DOAJ |
| description | Adamantinoma (AD) is a rare, slow-growing primary malignant bone tumor characterized by a biphasic morphology of clusters of epithelial cells and spindle cell osteofibrous components. A strong relationship between AD and osteofibrous dysplasia (OFD) has been proposed, while fibrous dysplasia (FD) has been rarely associated with AD. We present an AD case that was followed and histologically evaluated 3 times over 6 years with different morphological patterns. The tumor in the primary biopsy and after complete resection showed classical features of AD and osteofibrous-like pattern, while the recurrent lesion presented with exclusively spindle cell morphology and was thus diagnosed as FD. However, the extensive immunohistochemical analysis in all 3 lesions revealed strong reactivity for pancytokeratin, vimentin, p63, and podoplanin, which are characteristic for AD. Although, in the FD-like section of the tumor from the first recurrence the positivity of podoplanin was stronger than pancitokeratin, which was variably positive on spindle cells. The present case highlights the problem of diagnosing AD based on a single biopsy with one tumor’s component predominating over the other, and at the same time emphasizes the importance of using immunohistochemical staining for keratin and podoplanin when the histopathological features of (osteo)fibrous lesion can be linked to AD. |
| first_indexed | 2024-04-24T12:02:09Z |
| format | Article |
| id | doaj.art-a1207645cb6445ecae31a60959540205 |
| institution | Directory Open Access Journal |
| issn | 2632-010X |
| language | English |
| last_indexed | 2024-04-24T12:02:09Z |
| publishDate | 2024-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Pathology |
| spelling | doaj.art-a1207645cb6445ecae31a609595402052024-04-08T17:03:19ZengSAGE PublishingClinical Pathology2632-010X2024-04-011710.1177/2632010X241240391Recurrent Adamantinoma With Fibrous Dysplasia-like FeatureAnja Petaros0Veljko Šantić1Anita Savić Vuković2Petar Perić3Nives Jonjić4Department of Forensic Medicine and Criminalistics, Faculty of Medicine, University of Rijeka, Rijeka, CroatiaUniversity Hospital for Orthopaedic Surgery Lovran, Lovran, CroatiaDepartment of Pathology, Faculty of Medicine, University of Rijeka, Rijeka, CroatiaUniversity Hospital for Orthopaedic Surgery Lovran, Lovran, CroatiaDepartment of Pathology, Faculty of Medicine, University of Rijeka, Rijeka, CroatiaAdamantinoma (AD) is a rare, slow-growing primary malignant bone tumor characterized by a biphasic morphology of clusters of epithelial cells and spindle cell osteofibrous components. A strong relationship between AD and osteofibrous dysplasia (OFD) has been proposed, while fibrous dysplasia (FD) has been rarely associated with AD. We present an AD case that was followed and histologically evaluated 3 times over 6 years with different morphological patterns. The tumor in the primary biopsy and after complete resection showed classical features of AD and osteofibrous-like pattern, while the recurrent lesion presented with exclusively spindle cell morphology and was thus diagnosed as FD. However, the extensive immunohistochemical analysis in all 3 lesions revealed strong reactivity for pancytokeratin, vimentin, p63, and podoplanin, which are characteristic for AD. Although, in the FD-like section of the tumor from the first recurrence the positivity of podoplanin was stronger than pancitokeratin, which was variably positive on spindle cells. The present case highlights the problem of diagnosing AD based on a single biopsy with one tumor’s component predominating over the other, and at the same time emphasizes the importance of using immunohistochemical staining for keratin and podoplanin when the histopathological features of (osteo)fibrous lesion can be linked to AD.https://doi.org/10.1177/2632010X241240391 |
| spellingShingle | Anja Petaros Veljko Šantić Anita Savić Vuković Petar Perić Nives Jonjić Recurrent Adamantinoma With Fibrous Dysplasia-like Feature Clinical Pathology |
| title | Recurrent Adamantinoma With Fibrous Dysplasia-like Feature |
| title_full | Recurrent Adamantinoma With Fibrous Dysplasia-like Feature |
| title_fullStr | Recurrent Adamantinoma With Fibrous Dysplasia-like Feature |
| title_full_unstemmed | Recurrent Adamantinoma With Fibrous Dysplasia-like Feature |
| title_short | Recurrent Adamantinoma With Fibrous Dysplasia-like Feature |
| title_sort | recurrent adamantinoma with fibrous dysplasia like feature |
| url | https://doi.org/10.1177/2632010X241240391 |
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