Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma

Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma

Immune checkpoint modulation has been a vital therapeutic option in many malignancies, and targeting of novel immune checkpoints, including OX40/OX40L costimulatory signaling, is being assessed in clinical trials. However, little is known about the role of OX40 and OX40L in pancreatic ductal adenoca...

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Bibliographic Details
Main Authors: Xianlong Chen, Heng Ma, Shengwei Mo, Yue Zhang, Zhaohui Lu, Shuangni Yu, Jie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
OX40
OX40L
PD-L1
PDAC
immune checkpoint
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.942154/full

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