Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate
Background: Biodegradable hydrogel scaffold is one of the crucial characteristics that determine the success of pulp regeneration. The degradation should be suitable for the growth of new tissue establishment. The aim of this study is to synthesize and compare the novel biodegradable hydrogel scaffo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=38;epage=38;aulast=Elline |
| _version_ | 1797824454877773824 |
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| author | Elline Elline Kun Ismiyatin Theresia Indah Budhy |
| author_facet | Elline Elline Kun Ismiyatin Theresia Indah Budhy |
| author_sort | Elline Elline |
| collection | DOAJ |
| description | Background: Biodegradable hydrogel scaffold is one of the crucial characteristics that determine the success of pulp regeneration. The degradation should be suitable for the growth of new tissue establishment. The aim of this study is to synthesize and compare the novel biodegradable hydrogel scaffold based on hydroxyapatite (HAp) eggshell, collagen, and epigallocatechin-3-gallate (HAp-Col-EGCG) with different HAp concentrations in vitro.
Materials and Methods: This study is original research. HAp-Col-EGCG hydrogel scaffolds were prepared using 1:1, 1:2, and 1:4 ratios of collagen and HAp with 10 μmol/L EGCG. The samples were freeze-dried and immersed in phosphate buffer saline containing lysozyme enzyme. The dried samples were weighed to determine the percentage of biodegradation value (P < 0.05).
Results: The result showed HAp-Col-EGCG was biodegradable but it has not been concluded that it can be completely eliminated. The data were analyzed by one-way analysis of variance and it indicated significant differences in percentage values.
Conclusion: Hydrogel scaffold based on HAp-Col-EGCG can be degraded and have the potential to be used as a biodegradable scaffold in supporting tissue regeneration. |
| first_indexed | 2024-03-13T10:39:13Z |
| format | Article |
| id | doaj.art-a12463dcb21b48719e3ae04da0ef2957 |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-03-13T10:39:13Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-a12463dcb21b48719e3ae04da0ef29572023-05-18T05:13:29ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552023-01-01201383810.4103/1735-3327.372655Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallateElline EllineKun IsmiyatinTheresia Indah BudhyBackground: Biodegradable hydrogel scaffold is one of the crucial characteristics that determine the success of pulp regeneration. The degradation should be suitable for the growth of new tissue establishment. The aim of this study is to synthesize and compare the novel biodegradable hydrogel scaffold based on hydroxyapatite (HAp) eggshell, collagen, and epigallocatechin-3-gallate (HAp-Col-EGCG) with different HAp concentrations in vitro. Materials and Methods: This study is original research. HAp-Col-EGCG hydrogel scaffolds were prepared using 1:1, 1:2, and 1:4 ratios of collagen and HAp with 10 μmol/L EGCG. The samples were freeze-dried and immersed in phosphate buffer saline containing lysozyme enzyme. The dried samples were weighed to determine the percentage of biodegradation value (P < 0.05). Results: The result showed HAp-Col-EGCG was biodegradable but it has not been concluded that it can be completely eliminated. The data were analyzed by one-way analysis of variance and it indicated significant differences in percentage values. Conclusion: Hydrogel scaffold based on HAp-Col-EGCG can be degraded and have the potential to be used as a biodegradable scaffold in supporting tissue regeneration.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=38;epage=38;aulast=Ellinebiodegradablecollageneggshellepigallocatechin-3-gallatehydrogelhydroxyapatitescaffold |
| spellingShingle | Elline Elline Kun Ismiyatin Theresia Indah Budhy Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate Dental Research Journal biodegradable collagen eggshell epigallocatechin-3-gallate hydrogel hydroxyapatite scaffold |
| title | Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate |
| title_full | Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate |
| title_fullStr | Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate |
| title_full_unstemmed | Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate |
| title_short | Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate |
| title_sort | novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell collagen and epigallocatechin 3 gallate |
| topic | biodegradable collagen eggshell epigallocatechin-3-gallate hydrogel hydroxyapatite scaffold |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=38;epage=38;aulast=Elline |
| work_keys_str_mv | AT ellineelline novelbiodegradablehydrogelscaffoldbasedonhydroxyapatiteeggshellcollagenandepigallocatechin3gallate AT kunismiyatin novelbiodegradablehydrogelscaffoldbasedonhydroxyapatiteeggshellcollagenandepigallocatechin3gallate AT theresiaindahbudhy novelbiodegradablehydrogelscaffoldbasedonhydroxyapatiteeggshellcollagenandepigallocatechin3gallate |