The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
IntroductionWe aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years.Materials and MethodsWe utilised cross-sectional data from...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.850448/full |
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| author | Annie M. Constable Annie M. Constable Dimitris Vlachopoulos Alan R. Barker Sarah A. Moore Sonja Soininen Sonja Soininen Eero A. Haapala Eero A. Haapala Juuso Väistö Jarmo Jääskeläinen Raimo Voutilainen Seppo Auriola Merja R. Häkkinen Tomi Laitinen Timo A. Lakka Timo A. Lakka Timo A. Lakka |
| author_facet | Annie M. Constable Annie M. Constable Dimitris Vlachopoulos Alan R. Barker Sarah A. Moore Sonja Soininen Sonja Soininen Eero A. Haapala Eero A. Haapala Juuso Väistö Jarmo Jääskeläinen Raimo Voutilainen Seppo Auriola Merja R. Häkkinen Tomi Laitinen Timo A. Lakka Timo A. Lakka Timo A. Lakka |
| author_sort | Annie M. Constable |
| collection | DOAJ |
| description | IntroductionWe aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years.Materials and MethodsWe utilised cross-sectional data from the Physical Activity and Nutrition in Children study (n = 230 to 396; 112 to 203 girls). Fat mass and BMC were assessed with dual-energy X-ray absorptiometry. Endocrine factors were assessed from fasted blood samples. We applied the novel 4-way decomposition method to analyse associations between fat mass, endocrine factors, and BMC.ResultsFat mass was positively associated with BMC in girls (ß = 0.007 to 0.015, 95% confidence interval (CI) 0.005 to 0.020) and boys (ß = 0.009 to 0.015, 95% CI 0.005 to 0.019). The relationship between fat mass and BMC was mediated by free leptin index in girls (ß = -0.025, 95% CI -0.039 to -0.010) and boys (ß = -0.014, 95% CI -0.027 to -0.001). The relationship between fat mass and BMC was partially explained by mediated interaction between fat mass and free leptin index in boys (ß = -0.009, 95% CI -0.013 to -0.004) and by interaction between fat mass and adiponectin in girls (ß = -0.003, 95% CI -0.006 to -0.000).ConclusionAt greater levels of adiponectin and free leptin index, the fat mass and BMC relationship becomes less positive in girls and boys respectively. The positive association between fat mass with BMC was largely not explained by the endocrine factors we assessed.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT01803776], identifier NCT01803776. |
| first_indexed | 2024-12-22T20:39:07Z |
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| last_indexed | 2024-12-22T20:39:07Z |
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| spelling | doaj.art-a125dc2e8a0542caa271ba1349b0abdc2022-12-21T18:13:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.850448850448The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children StudyAnnie M. Constable0Annie M. Constable1Dimitris Vlachopoulos2Alan R. Barker3Sarah A. Moore4Sonja Soininen5Sonja Soininen6Eero A. Haapala7Eero A. Haapala8Juuso Väistö9Jarmo Jääskeläinen10Raimo Voutilainen11Seppo Auriola12Merja R. Häkkinen13Tomi Laitinen14Timo A. Lakka15Timo A. Lakka16Timo A. Lakka17Children’s Health and Exercise Research Centre, University of Exeter, Exeter, United KingdomInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandChildren’s Health and Exercise Research Centre, University of Exeter, Exeter, United KingdomChildren’s Health and Exercise Research Centre, University of Exeter, Exeter, United KingdomSchool of Health and Human Performance, Dalhousie University, Halifax, NS, CanadaInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandSocial and Health Center, City of Varkaus, FinlandInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandDepartment of Paediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, FinlandDepartment of Paediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, FinlandSchool of Pharmacy, University of Eastern Finland, Kuopio, FinlandSchool of Pharmacy, University of Eastern Finland, Kuopio, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FinlandInstitute of Biomedicine, University of Eastern Finland, Kuopio, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FinlandFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandIntroductionWe aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years.Materials and MethodsWe utilised cross-sectional data from the Physical Activity and Nutrition in Children study (n = 230 to 396; 112 to 203 girls). Fat mass and BMC were assessed with dual-energy X-ray absorptiometry. Endocrine factors were assessed from fasted blood samples. We applied the novel 4-way decomposition method to analyse associations between fat mass, endocrine factors, and BMC.ResultsFat mass was positively associated with BMC in girls (ß = 0.007 to 0.015, 95% confidence interval (CI) 0.005 to 0.020) and boys (ß = 0.009 to 0.015, 95% CI 0.005 to 0.019). The relationship between fat mass and BMC was mediated by free leptin index in girls (ß = -0.025, 95% CI -0.039 to -0.010) and boys (ß = -0.014, 95% CI -0.027 to -0.001). The relationship between fat mass and BMC was partially explained by mediated interaction between fat mass and free leptin index in boys (ß = -0.009, 95% CI -0.013 to -0.004) and by interaction between fat mass and adiponectin in girls (ß = -0.003, 95% CI -0.006 to -0.000).ConclusionAt greater levels of adiponectin and free leptin index, the fat mass and BMC relationship becomes less positive in girls and boys respectively. The positive association between fat mass with BMC was largely not explained by the endocrine factors we assessed.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT01803776], identifier NCT01803776.https://www.frontiersin.org/articles/10.3389/fendo.2022.850448/fulladiposityinsulinleptinadiponectinDXA (dual-energy X-ray absorptiometry)paediatric |
| spellingShingle | Annie M. Constable Annie M. Constable Dimitris Vlachopoulos Alan R. Barker Sarah A. Moore Sonja Soininen Sonja Soininen Eero A. Haapala Eero A. Haapala Juuso Väistö Jarmo Jääskeläinen Raimo Voutilainen Seppo Auriola Merja R. Häkkinen Tomi Laitinen Timo A. Lakka Timo A. Lakka Timo A. Lakka The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study Frontiers in Endocrinology adiposity insulin leptin adiponectin DXA (dual-energy X-ray absorptiometry) paediatric |
| title | The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study |
| title_full | The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study |
| title_fullStr | The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study |
| title_full_unstemmed | The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study |
| title_short | The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study |
| title_sort | mediating role of endocrine factors in the positive relationship between fat mass and bone mineral content in children aged 9 11 years the physical activity and nutrition in children study |
| topic | adiposity insulin leptin adiponectin DXA (dual-energy X-ray absorptiometry) paediatric |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.850448/full |
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