Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature
Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.833864/full |
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| author | Changhong Wei Changhong Wei Yili Ma Dengqiang Wu Xiaoyu Chen Chunjun Li Jun Chen Sufang Zhou Sufang Zhou |
| author_facet | Changhong Wei Changhong Wei Yili Ma Dengqiang Wu Xiaoyu Chen Chunjun Li Jun Chen Sufang Zhou Sufang Zhou |
| author_sort | Changhong Wei |
| collection | DOAJ |
| description | Sclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition deteriorated. Enhanced CT showed that the right posterior upper chest wall mass invaded the adjacent bone, and the boundary between the lesion and the surrounding tissues was relatively clear. She then underwent posterior tumor removal surgery. The pathological examination confirmed the diagnosis of SEF. In histomorphology, the tumor displayed a typical epithelioid clear cell morphology, accompanied by extensive vitrification and fibrosis, which better helped to differentiate the tumor from low grade fibromyxoid sarcoma, solitary fibrous tumor and other entities. The immunohistochemical analysis showed a diffuse positive reaction to MUC4, a highly specific marker of SEF, which was detected by Immunohistochemistry (IHC), and fluorescence in-situ hybridization (FISH) confirmed that the EWSR1 gene was rearranged, while the FUS gene was not rearranged. This is the first time that we have encountered such this rare case and thus report this case with updated literature related to this tumor. |
| first_indexed | 2024-04-12T12:19:08Z |
| format | Article |
| id | doaj.art-a126185ad00c47d39771559397222557 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T12:19:08Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a126185ad00c47d397715593972225572022-12-22T03:33:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.833864833864Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of LiteratureChanghong Wei0Changhong Wei1Yili Ma2Dengqiang Wu3Xiaoyu Chen4Chunjun Li5Jun Chen6Sufang Zhou7Sufang Zhou8Department of Pathology, Guangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Key Laboratory of Bio-Targeting Theranostics, National Center for International Research of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, ChinaDepartment of Biochemistry and Molecular Biology, School of Pre-clinical Science, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Bio-Targeting Theranostics, National Center for International Research of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, ChinaDepartment of Pathology, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Pathology, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Pathology, Guangxi Medical University Cancer Hospital, Nanning, ChinaGuangxi Key Laboratory of Bio-Targeting Theranostics, National Center for International Research of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, ChinaDepartment of Biochemistry and Molecular Biology, School of Pre-clinical Science, Guangxi Medical University, Nanning, ChinaSclerosing epithelioid fibrosarcoma (SEF) is a rare subtype of soft tissue tumors, and SEF originating from the side of the spine is even rarer. We report that a 28-year-old young woman suffered from chest pain and back pain for 3 years, and thereafter she went to see a doctor because her condition deteriorated. Enhanced CT showed that the right posterior upper chest wall mass invaded the adjacent bone, and the boundary between the lesion and the surrounding tissues was relatively clear. She then underwent posterior tumor removal surgery. The pathological examination confirmed the diagnosis of SEF. In histomorphology, the tumor displayed a typical epithelioid clear cell morphology, accompanied by extensive vitrification and fibrosis, which better helped to differentiate the tumor from low grade fibromyxoid sarcoma, solitary fibrous tumor and other entities. The immunohistochemical analysis showed a diffuse positive reaction to MUC4, a highly specific marker of SEF, which was detected by Immunohistochemistry (IHC), and fluorescence in-situ hybridization (FISH) confirmed that the EWSR1 gene was rearranged, while the FUS gene was not rearranged. This is the first time that we have encountered such this rare case and thus report this case with updated literature related to this tumor.https://www.frontiersin.org/articles/10.3389/fmed.2022.833864/fullsoft tissue sarcomasclerosing epithelioid fibrosarcomaimmunohistochemistryfishEWSR1 |
| spellingShingle | Changhong Wei Changhong Wei Yili Ma Dengqiang Wu Xiaoyu Chen Chunjun Li Jun Chen Sufang Zhou Sufang Zhou Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature Frontiers in Medicine soft tissue sarcoma sclerosing epithelioid fibrosarcoma immunohistochemistry fish EWSR1 |
| title | Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature |
| title_full | Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature |
| title_fullStr | Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature |
| title_full_unstemmed | Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature |
| title_short | Sclerosing Epithelioid Fibrosarcoma of the Thoracic Vertebrae: An Fairly Unusual Case Report With a Short Review of Literature |
| title_sort | sclerosing epithelioid fibrosarcoma of the thoracic vertebrae an fairly unusual case report with a short review of literature |
| topic | soft tissue sarcoma sclerosing epithelioid fibrosarcoma immunohistochemistry fish EWSR1 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.833864/full |
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