Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-01652-0 |
| _version_ | 1830208060008693760 |
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| author | Corrado Pedrazzani Guido Mantovani Eduardo Fernandes Fabio Bagante Gian Luca Salvagno Niccolò Surci Tommaso Campagnaro Andrea Ruzzenente Elisa Danese Giuseppe Lippi Alfredo Guglielmi |
| author_facet | Corrado Pedrazzani Guido Mantovani Eduardo Fernandes Fabio Bagante Gian Luca Salvagno Niccolò Surci Tommaso Campagnaro Andrea Ruzzenente Elisa Danese Giuseppe Lippi Alfredo Guglielmi |
| author_sort | Corrado Pedrazzani |
| collection | DOAJ |
| description | Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival of patients with colorectal cancer (CRC). Receiver operating characteristic (ROC) curve analysis was performed to define cut-off values for high and low ratios of these indices. Univariate and multivariate analysis were used to determine the prognostic value of NLR, PLR and PC for overall and cancer-related survival. The distribution of NLR, PLR and PC in CRC patients was compared with 5270 healthy blood donors. The distribution of NLR, PLR and PC was significantly different between CRC patients and controls (all p < 0.05). A significant but heterogeneous association was found between the main CRC prognostic factors and high values of NLR, PLR and PC. Survival appeared to be worse in patients with high NLR with cancers in AJCC/UICC TNM Stages I-IV; nonetheless its prognostic value was not confirmed for cancer-related survival in multivariate analysis. After stratification of patients according to AJCC/UICC TNM stages, high PC value was significantly correlated with overall and cancer-related survival in TNM stage IV patients. |
| first_indexed | 2024-12-18T04:43:01Z |
| format | Article |
| id | doaj.art-a12a16f843aa40acb704d1d4b36b82fd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:43:01Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a12a16f843aa40acb704d1d4b36b82fd2022-12-21T21:20:40ZengNature PortfolioScientific Reports2045-23222017-05-017111010.1038/s41598-017-01652-0Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancerCorrado Pedrazzani0Guido Mantovani1Eduardo Fernandes2Fabio Bagante3Gian Luca Salvagno4Niccolò Surci5Tommaso Campagnaro6Andrea Ruzzenente7Elisa Danese8Giuseppe Lippi9Alfredo Guglielmi10Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaDivision of Minimally Invasive, General and Robotic Surgery, University of Illinois at ChicagoDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaSection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of VeronaDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaSection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of VeronaSection of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of VeronaDivision of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaAbstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival of patients with colorectal cancer (CRC). Receiver operating characteristic (ROC) curve analysis was performed to define cut-off values for high and low ratios of these indices. Univariate and multivariate analysis were used to determine the prognostic value of NLR, PLR and PC for overall and cancer-related survival. The distribution of NLR, PLR and PC in CRC patients was compared with 5270 healthy blood donors. The distribution of NLR, PLR and PC was significantly different between CRC patients and controls (all p < 0.05). A significant but heterogeneous association was found between the main CRC prognostic factors and high values of NLR, PLR and PC. Survival appeared to be worse in patients with high NLR with cancers in AJCC/UICC TNM Stages I-IV; nonetheless its prognostic value was not confirmed for cancer-related survival in multivariate analysis. After stratification of patients according to AJCC/UICC TNM stages, high PC value was significantly correlated with overall and cancer-related survival in TNM stage IV patients.https://doi.org/10.1038/s41598-017-01652-0 |
| spellingShingle | Corrado Pedrazzani Guido Mantovani Eduardo Fernandes Fabio Bagante Gian Luca Salvagno Niccolò Surci Tommaso Campagnaro Andrea Ruzzenente Elisa Danese Giuseppe Lippi Alfredo Guglielmi Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer Scientific Reports |
| title | Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer |
| title_full | Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer |
| title_fullStr | Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer |
| title_full_unstemmed | Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer |
| title_short | Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer |
| title_sort | assessment of neutrophil to lymphocyte ratio platelet to lymphocyte ratio and platelet count as predictors of long term outcome after r0 resection for colorectal cancer |
| url | https://doi.org/10.1038/s41598-017-01652-0 |
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